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@ARTICLE{TejadaNeyra:141686,
      author       = {M. A. Tejada Neyra and U. Neuberger and A. Reinhardt and G.
                      Brugnara and D. Bonekamp$^*$ and M. Sill$^*$ and A. Wick and
                      D. Jones$^*$ and A. Radbruch$^*$ and A. Unterberg and J.
                      Debus$^*$ and S. Heiland and H.-P. Schlemmer$^*$ and C.
                      Herold-Mende and S. Pfister$^*$ and A. von Deimling$^*$ and
                      W. Wick and D. Capper$^*$ and M. Bendszus and P.
                      Kickingereder},
      title        = {{V}oxel-wise radiogenomic mapping of tumor location with
                      key molecular alterations in patients with glioma.},
      journal      = {Neuro-Oncology},
      volume       = {20},
      number       = {11},
      issn         = {1523-5866},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2018-01957},
      pages        = {1517 - 1524},
      year         = {2018},
      abstract     = {This study aims to evaluate the impact of tumor location on
                      key molecular alterations on a single voxel level in
                      patients with newly diagnosed glioma.A consecutive series of
                      n = 237 patients with newly diagnosed glioblastoma and n =
                      131 patients with lower-grade glioma was analyzed.
                      Volumetric tumor segmentation was performed on preoperative
                      MRI with a semi-automated approach and images were
                      registered to the standard Montreal Neurological Institute
                      152 space. Using a voxel-based lesion symptom mapping (VLSM)
                      analysis, we identified specific brain regions that were
                      associated with tumor-specific molecular alterations. We
                      assessed a predefined set of n = 17 molecular
                      characteristics in the glioblastoma cohort and n = 2
                      molecular characteristics in the lower-grade glioma cohort.
                      Permutation adjustment (n = 1000 iterations) was used to
                      correct for multiple testing, and voxel t-values that were
                      greater than the t-value in $>95\%$ of the permutations were
                      retained in the VLSM results (α = 0.05, power > 0.8).Tumor
                      location predilection for isocitrate dehydrogenase (IDH)
                      mutant tumors was found in both glioblastoma and lower-grade
                      glioma cohorts, each showing a concordant predominance in
                      the frontal lobe adjacent to the rostral extension of the
                      lateral ventricles (permutation-adjusted P = 0.021 for the
                      glioblastoma and 0.013 for the lower-grade glioma cohort).
                      Apart from that, the VLSM analysis did not reveal a
                      significant association of the tumor location with any other
                      key molecular alteration in both cohorts
                      (permutation-adjusted P > 0.05 each).Our study highlights
                      the unique properties of IDH mutations and underpins the
                      hypothesis that the rostral extension of the lateral
                      ventricles is a potential location for the cell of origin in
                      IDH-mutant gliomas.},
      cin          = {E010 / G370 / L101 / B062 / E050 / G380 / L201},
      ddc          = {610},
      cid          = {I:(DE-He78)E010-20160331 / I:(DE-He78)G370-20160331 /
                      I:(DE-He78)L101-20160331 / I:(DE-He78)B062-20160331 /
                      I:(DE-He78)E050-20160331 / I:(DE-He78)G380-20160331 /
                      I:(DE-He78)L201-20160331},
      pnm          = {319H - Addenda (POF3-319H)},
      pid          = {G:(DE-HGF)POF3-319H},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30107597},
      pmc          = {pmc:PMC6176804},
      doi          = {10.1093/neuonc/noy134},
      url          = {https://inrepo02.dkfz.de/record/141686},
}