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| 001 | 141686 | ||
| 005 | 20240229105128.0 | ||
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| 100 | 1 | _ | |a Tejada Neyra, Miguel Angel |b 0 |
| 245 | _ | _ | |a Voxel-wise radiogenomic mapping of tumor location with key molecular alterations in patients with glioma. |
| 260 | _ | _ | |a Oxford |c 2018 |b Oxford Univ. Press |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a This study aims to evaluate the impact of tumor location on key molecular alterations on a single voxel level in patients with newly diagnosed glioma.A consecutive series of n = 237 patients with newly diagnosed glioblastoma and n = 131 patients with lower-grade glioma was analyzed. Volumetric tumor segmentation was performed on preoperative MRI with a semi-automated approach and images were registered to the standard Montreal Neurological Institute 152 space. Using a voxel-based lesion symptom mapping (VLSM) analysis, we identified specific brain regions that were associated with tumor-specific molecular alterations. We assessed a predefined set of n = 17 molecular characteristics in the glioblastoma cohort and n = 2 molecular characteristics in the lower-grade glioma cohort. Permutation adjustment (n = 1000 iterations) was used to correct for multiple testing, and voxel t-values that were greater than the t-value in >95% of the permutations were retained in the VLSM results (α = 0.05, power > 0.8).Tumor location predilection for isocitrate dehydrogenase (IDH) mutant tumors was found in both glioblastoma and lower-grade glioma cohorts, each showing a concordant predominance in the frontal lobe adjacent to the rostral extension of the lateral ventricles (permutation-adjusted P = 0.021 for the glioblastoma and 0.013 for the lower-grade glioma cohort). Apart from that, the VLSM analysis did not reveal a significant association of the tumor location with any other key molecular alteration in both cohorts (permutation-adjusted P > 0.05 each).Our study highlights the unique properties of IDH mutations and underpins the hypothesis that the rostral extension of the lateral ventricles is a potential location for the cell of origin in IDH-mutant gliomas. |
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| 700 | 1 | _ | |a Neuberger, Ulf |b 1 |
| 700 | 1 | _ | |a Reinhardt, Annekathrin |b 2 |
| 700 | 1 | _ | |a Brugnara, Gianluca |b 3 |
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| 700 | 1 | _ | |a Wick, Antje |b 6 |
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| 700 | 1 | _ | |a Radbruch, Alexander |0 P:(DE-He78)77588f5b9413339755a66e739d316c7d |b 8 |u dkfz |
| 700 | 1 | _ | |a Unterberg, Andreas |b 9 |
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| 700 | 1 | _ | |a Heiland, Sabine |b 11 |
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| 700 | 1 | _ | |a Herold-Mende, Christel |b 13 |
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| 700 | 1 | _ | |a Bendszus, Martin |b 18 |
| 700 | 1 | _ | |a Kickingereder, Philipp |b 19 |
| 773 | _ | _ | |a 10.1093/neuonc/noy134 |g Vol. 20, no. 11, p. 1517 - 1524 |0 PERI:(DE-600)2094060-9 |n 11 |p 1517 - 1524 |t Neuro-Oncology |v 20 |y 2018 |x 1523-5866 |
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