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000141688 0247_ $$2ISSN$$a1795-990X
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000141688 037__ $$aDKFZ-2018-01959
000141688 041__ $$aeng
000141688 082__ $$a610
000141688 1001_ $$aOlsson, Ann$$b0
000141688 245__ $$aParental occupational exposure to solvents and heavy metals and risk of developing testicular germ cell tumors in sons (NORD-TEST Denmark).
000141688 260__ $$aHelsinki$$bFinnish Inst. of Occupational Health$$c2018
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000141688 520__ $$aObjective The present study aims to assess if parental occupational exposure to solvents or heavy metals is associated with risk of testicular germ cell tumors (TGCT) in sons in Denmark. Methods The NORD-TEST Denmark included 3421 cases diagnosed with TGCT at ages 14-49 years in Denmark between 1981 and 2014. Controls (N=14 024) selected from the central population registry were matched to cases on birth year. The Danish Supplementary Pension Fund provided parental occupational information. A job-exposure matrix was used to assign exposures, and conditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results The overall analyses showed no significant associations except for paternal exposure to a sub-group of 'heavy metal(s) and solvent(s)' (OR 1.50, 95% CI 1.01-2.24). Most fathers in this category had worked in wood related jobs and were assigned exposure to chromium VI and toluene. Other sub-group analyses suggested that maternal exposure to aromatic hydrocarbon were associated with TGCT risk, in sons born in 1970-1979, and to heavy metals (chromium, iron and nickel) in sons born in 1980-1998. Conclusion NORD-TEST Denmark provides no strong support for an association between parental exposures to solvents or heavy metals and TGCT in sons, and only weak support for an association between paternal exposure to chromium and toluene and TGCT risk in sons.
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000141688 7001_ $$aTogawa, Kayo$$b1
000141688 7001_ $$aSchüz, Joachim$$b2
000141688 7001_ $$0P:(DE-He78)2d4cac0f4bf270325b98fe07036dc6c6$$aLe Cornet, Charlotte$$b3$$udkfz
000141688 7001_ $$aFervers, Beatrice$$b4
000141688 7001_ $$aOksbjerg Dalton, Susanne$$b5
000141688 7001_ $$aPukkala, Eero$$b6
000141688 7001_ $$aMaria Feychting, Maria Feychting$$b7
000141688 7001_ $$aSkakkebæk, Niels Erik$$b8
000141688 7001_ $$aHansen, Johnni$$b9
000141688 773__ $$0PERI:(DE-600)2083318-0$$a10.5271/sjweh.3732$$gVol. 44, no. 6, p. 658 - 669$$n6$$p658 - 669$$tScandinavian journal of work, environment & health$$v44$$x1795-990X$$y2018
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