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@ARTICLE{Rohrmann:141691,
      author       = {S. Rohrmann$^*$ and V. Katzke$^*$ and R. Kaaks$^*$},
      title        = {{L}ifestyle and {P}rogression of {L}ower {U}rinary {T}ract
                      {S}ymptoms in {G}erman {M}en-{R}esults {F}rom the
                      {EPIC}-{H}eidelberg {C}ohort.},
      journal      = {Urology},
      volume       = {120},
      issn         = {0090-4295},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2018-01962},
      pages        = {192 - 196},
      year         = {2018},
      abstract     = {To examine if lower urinary tract symptom (LUTS)
                      progression was related to anthropometric and lifestyle
                      factors.The analysis included 5495 men who participated in
                      the EPIC-Heidelberg cohort (recruited 1994-1998) and who
                      reported an International Prostate Symptom Score < 8 at
                      follow-up 4 (FUP4, 2007-2009), had not reported taking
                      α-adrenoreceptor antagonists or 5-α reductase inhibitors
                      or prostate surgery for benign prostatic hyperplasia/LUTS
                      treatment. LUTS progression was defined as an International
                      Prostate Symptom Score ≥ 8 at FUP5 (2010-2012). Using
                      logistic regression analysis, education, marital status,
                      satisfaction with life, satisfaction with health, history of
                      diabetes and of hypertension, smoking, alcohol consumption,
                      body mass index (BMI), waist circumference, and physical
                      activity were examined as potential LUTS risk factors
                      adjusting for age.Increase in BMI between baseline and FUP4
                      of ≥ 2 BMI units was related to LUTS progression (odds
                      ratio 1.30, $95\%$ confidence interval 1.08-1.57) compared
                      with stable BMI. Compared to men who were very satisfied
                      with life at baseline, those who were satisfied (1.28,
                      1.11-1.47), unsatisfied (1.80, 1.31-2.46) or very
                      unsatisfied with life (1.43, 0.62-3.34) were more likely to
                      report LUTS progression. Men with longer education had
                      higher odds of LUTS progression than men with primary
                      education only (1.25, 1.06-1.48). Adjusting for BMI or
                      lifestyle factors did not attenuate these associations.
                      Smoking habits, alcohol consumption, physical activity,
                      self-reported history of diabetes or hypertension, and
                      marital status were not related with LUTS progression.Our
                      results confirm some, but not all previously observed risk
                      factors for LUTS progression.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29940234},
      doi          = {10.1016/j.urology.2018.06.013},
      url          = {https://inrepo02.dkfz.de/record/141691},
}