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@ARTICLE{Shu:141705,
author = {X. Shu and L. Wu and N. K. Khankari and X.-O. Shu and T. J.
Wang and K. Michailidou and M. K. Bolla and Q. Wang and J.
Dennis and R. L. Milne and M. K. Schmidt and P. D. P.
Pharoah and I. L. Andrulis and D. J. Hunter and J. Simard
and D. F. Easton and W. Zheng and B. J. Alicia and H.
Anton-Culver and N. N. Antonenkova and V. Arndt$^*$ and K.
J. Aronson and P. L. Auer and M. Barrdahl$^*$ and C. Baynes
and L. E. Beane Freeman and M. W. Beckmann and S.
Behrens$^*$ and J. Benitez and M. Bermisheva and C.
Blomqvist and N. V. Bogdanova and S. E. Bojesen and H.
Brauch and H. Brenner$^*$ and L. Brinton and P. Broberg and
S. Y. Brucker and T. Brüning and B. Burwinkel$^*$ and Q.
Cai and T. Caldés and F. Canzian$^*$ and B. D. Carter and
J. E. Castelao and J. Chang-Claude$^*$ and G.
Chenevix-Trench and T.-Y. David Cheng and C. L. Clarke and
D. M. Conroy and F. J. Couch and D. G. Cox and A. Cox and S.
S. Cross and J. M. Cunningham and K. Czene and M. B. Daly
and K. F. Doheny and T. Dörk and I. Dos-Santos-Silva and M.
Dumont and A. M. Dunning and M. Dwek and H. S. Earp and D.
M. Eccles and A. Heather Eliassen and C. Engel and M.
Eriksson and D. Gareth Evans and L. Fachal and P. A.
Fasching and J. Figueroa and O. Fletcher and H. Flyger and
L. Fritschi and M. Gabrielson and M. Gago-Dominguez and S.
M. Gapstur and M. García-Closas and M. M. Gaudet and M.
Ghoussaini and G. G. Giles and M. S. Goldberg and D. E.
Goldgar and A. González-Neira and P. Guénel and E. Hahnen
and C. A. Haiman and N. Håkansson and P. Hall and E.
Hallberg and U. Hamann$^*$ and P. Harrington and W. He and
A. Hein and B. Hicks and P. Hillemanns and F. B. Hogervorst
and A. Hollestelle and R. N. Hoover and J. L. Hopper and A.
Howell and G. Huang and A. Jakubowska and W. Janni and E. M.
John and N. Johnson and K. Jones and A. Jung and R.
Kaaks$^*$ and M. Kabisch and M. J. Kerin and E.
Khusnutdinova and C. M. Kitahara and V.-M. Kosma and S.
Koutros and P. Kraft and V. N. Kristensen and D. Lambrechts
and L. Le Marchand and S. Lindström and M. S. Linet and J.
Lissowska and S. Loibl and J. Lubinski and C. Luccarini and
M. P. Lux and T. Maishman and I. M. Kostovska and A.
Mannermaa and S. Manoukian and J. E. Manson and S. Margolin
and D. Mavroudis and H. Meijers-Heijboer and A. Meindl and
U. Menon and J. Meyer and A. M. Mulligan and S. L. Neuhausen
and H. Nevanlinna and P. Neven and W. T. Newman and S. F.
Nielsen and B. G. Nordestgaard and O. I. Olopade and A. F.
Olshan and J. E. Olson and H. Olsson and C. Olswold and N.
Orr and C. M. Perou and J. Peto and D. Plaseska-Karanfilska
and R. Prentice and N. Presneau and K. Pylkäs and B. Rack
and P. Radice and N. Rahman and G. Rennert and H. S. Rennert
and A. Romero and J. Romm and E. Saloustros and D. P.
Sandler and E. J. Sawyer and R. K. Schmutzler and A.
Schneeweiss and R. J. Scott and C. Scott and S. Seal and C.
Seynaeve and A. Smeets and M. C. Southey and J. J. Spinelli
and J. Stone and H. Surowy and A. J. Swerdlow and R. Tamimi
and W. Tapper and J. A. Taylor and M. B. Terry and D. C.
Tessier and K. Thöne and R. A. E. M. Tollenaar and D.
Torres and M. A. Troester and T. Truong and M. Untch and C.
Vachon and D. Van Den Berg and A. M. W. van den Ouweland and
E. M. van Veen and D. Vincent and Q. Waisfisz and C. R.
Weinberg and C. Wendt and A. S. Whittemore and H. Wildiers
and R. Winqvist and A. Wolk and L. Xia and X. R. Yang and A.
Ziogas and E. Ziv},
collaboration = {B. C. A. Consortium},
title = {{A}ssociations of obesity and circulating insulin and
glucose with breast cancer risk: a {M}endelian randomization
analysis.},
journal = {International journal of epidemiology},
volume = {48},
number = {3},
issn = {1464-3685},
address = {Oxford},
publisher = {Oxford Univ. Press},
reportid = {DKFZ-2018-01976},
pages = {795-806},
year = {2019},
abstract = {In addition to the established association between general
obesity and breast cancer risk, central obesity and
circulating fasting insulin and glucose have been linked to
the development of this common malignancy. Findings from
previous studies, however, have been inconsistent, and the
nature of the associations is unclear.We conducted Mendelian
randomization analyses to evaluate the association of breast
cancer risk, using genetic instruments, with fasting
insulin, fasting glucose, 2-h glucose, body mass index (BMI)
and BMI-adjusted waist-hip-ratio (WHRadj BMI). We first
confirmed the association of these instruments with type 2
diabetes risk in a large diabetes genome-wide association
study consortium. We then investigated their associations
with breast cancer risk using individual-level data obtained
from 98 842 cases and 83 464 controls of European descent
in the Breast Cancer Association Consortium.All sets of
instruments were associated with risk of type 2 diabetes.
Associations with breast cancer risk were found for
genetically predicted fasting insulin [odds ratio (OR) =
1.71 per standard deviation (SD) increase, $95\%$ confidence
interval (CI) = 1.26-2.31, p = 5.09 ×
10-4], 2-h glucose (OR = 1.80 per SD increase, $95\%$
CI = 1.3 0-2.49, p = 4.02 × 10-4), BMI
(OR = 0.70 per 5-unit increase, $95\%$
CI = 0.65-0.76, p = 5.05 × 10-19) and
WHRadj BMI (OR = 0.85, $95\%$ CI = 0.79-0.91, p =
9.22 × 10-6). Stratified analyses showed that
genetically predicted fasting insulin was more closely
related to risk of estrogen-receptor [ER]-positive cancer,
whereas the associations with instruments of 2-h glucose,
BMI and WHRadj BMI were consistent regardless of age,
menopausal status, estrogen receptor status and family
history of breast cancer.We confirmed the previously
reported inverse association of genetically predicted BMI
with breast cancer risk, and showed a positive association
of genetically predicted fasting insulin and 2-h glucose and
an inverse association of WHRadj BMI with breast cancer
risk. Our study suggests that genetically determined obesity
and glucose/insulin-related traits have an important role in
the aetiology of breast cancer.},
cin = {C071 / C020 / C070 / C080 / C055 / B072},
ddc = {610},
cid = {I:(DE-He78)C071-20160331 / I:(DE-He78)C020-20160331 /
I:(DE-He78)C070-20160331 / I:(DE-He78)C080-20160331 /
I:(DE-He78)C055-20160331 / I:(DE-He78)B072-20160331},
pnm = {319H - Addenda (POF3-319H)},
pid = {G:(DE-HGF)POF3-319H},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:30277539},
doi = {10.1093/ije/dyy201},
url = {https://inrepo02.dkfz.de/record/141705},
}
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