TY  - JOUR
AU  - Schoemaker, Minouk J
AU  - Nichols, Hazel B
AU  - Wright, Lauren B
AU  - Brook, Mark N
AU  - Jones, Michael E
AU  - O'Brien, Katie M
AU  - Adami, Hans-Olov
AU  - Baglietto, Laura
AU  - Bernstein, Leslie
AU  - Bertrand, Kimberly A
AU  - Boutron-Ruault, Marie-Christine
AU  - Braaten, Tonje
AU  - Chen, Yu
AU  - Connor, Avonne E
AU  - Dorronsoro, Miren
AU  - Dossus, Laure
AU  - Eliassen, A Heather
AU  - Giles, Graham G
AU  - Hankinson, Susan E
AU  - Kaaks, Rudolf
AU  - Key, Timothy J
AU  - Kirsh, Victoria A
AU  - Kitahara, Cari M
AU  - Koh, Woon-Puay
AU  - Larsson, Susanna C
AU  - Linet, Martha S
AU  - Ma, Huiyan
AU  - Masala, Giovanna
AU  - Merritt, Melissa A
AU  - Milne, Roger L
AU  - Overvad, Kim
AU  - Ozasa, Kotaro
AU  - Palmer, Julie R
AU  - Peeters, Petra H
AU  - Riboli, Elio
AU  - Rohan, Thomas E
AU  - Sadakane, Atsuko
AU  - Sund, Malin
AU  - Tamimi, Rulla M
AU  - Trichopoulou, Antonia
AU  - Ursin, Giske
AU  - Vatten, Lars
AU  - Visvanathan, Kala
AU  - Weiderpass, Elisabete
AU  - Willett, Walter C
AU  - Wolk, Alicja
AU  - Yuan, Jian-Min
AU  - Zeleniuch-Jacquotte, Anne
AU  - Sandler, Dale P
AU  - Swerdlow, Anthony J
TI  - Association of Body Mass Index and Age With Subsequent Breast Cancer Risk in Premenopausal Women.
JO  - JAMA oncology
VL  - 4
IS  - 11
SN  - 2374-2437
CY  - Chicago, Ill.
PB  - American Medical Association
M1  - DKFZ-2018-01978
SP  - e181771
PY  - 2018
AB  - The association between increasing body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) and risk of breast cancer is unique in cancer epidemiology in that a crossover effect exists, with risk reduction before and risk increase after menopause. The inverse association with premenopausal breast cancer risk is poorly characterized but might be important in the understanding of breast cancer causation.To investigate the association of BMI with premenopausal breast cancer risk, in particular by age at BMI, attained age, risk factors for breast cancer, and tumor characteristics.This multicenter analysis used pooled individual-level data from 758 592 premenopausal women from 19 prospective cohorts to estimate hazard ratios (HRs) of premenopausal breast cancer in association with BMI from ages 18 through 54 years using Cox proportional hazards regression analysis. Median follow-up was 9.3 years (interquartile range, 4.9-13.5 years) per participant, with 13 082 incident cases of breast cancer. Participants were recruited from January 1, 1963, through December 31, 2013, and data were analyzed from September 1, 2013, through December 31, 2017.Body mass index at ages 18 to 24, 25 to 34, 35 to 44, and 45 to 54 years.Invasive or in situ premenopausal breast cancer.Among the 758 592 premenopausal women (median age, 40.6 years; interquartile range, 35.2-45.5 years) included in the analysis, inverse linear associations of BMI with breast cancer risk were found that were stronger for BMI at ages 18 to 24 years (HR per 5 kg/m2 [5.0-U] difference, 0.77; 95
LB  - PUB:(DE-HGF)16
C6  - pmid:29931120
DO  - DOI:10.1001/jamaoncol.2018.1771
UR  - https://inrepo02.dkfz.de/record/141707
ER  -