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000141709 1001_ $$aOng, Jue-Sheng$$b0
000141709 245__ $$aAssessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study.
000141709 260__ $$aOxford$$bOxford Univ. Press$$c2018
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000141709 520__ $$aCoffee consumption has been shown to be associated with various health outcomes in observational studies. However, evidence for its association with epithelial ovarian cancer (EOC) is inconsistent and it is unclear whether these associations are causal.We used single nucleotide polymorphisms associated with (i) coffee and (ii) caffeine consumption to perform Mendelian randomization (MR) on EOC risk. We conducted a two-sample MR using genetic data on 44 062 individuals of European ancestry from the Ovarian Cancer Association Consortium (OCAC), and combined instrumental variable estimates using a Wald-type ratio estimator.For all EOC cases, the causal odds ratio (COR) for genetically predicted consumption of one additional cup of coffee per day was 0.92 [95% confidence interval (CI): 0.79, 1.06]. The COR was 0.90 (95% CI: 0.73, 1.10) for high-grade serous EOC. The COR for genetically predicted consumption of an additional 80 mg caffeine was 1.01 (95% CI: 0.92, 1.11) for all EOC cases and 0.90 (95% CI: 0.73, 1.10) for high-grade serous cases.We found no evidence indicative of a strong association between EOC risk and genetically predicted coffee or caffeine levels. However, our estimates were not statistically inconsistent with earlier observational studies and we were unable to rule out small protective associations.
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000141709 7001_ $$aCuellar-Partida, Gabriel$$b2
000141709 7001_ $$aMartin, Nicholas G$$b3
000141709 7001_ $$aChenevix-Trench, Georgia$$b4
000141709 7001_ $$aQuinn, Michael C J$$b5
000141709 7001_ $$aCornelis, Marilyn C$$b6
000141709 7001_ $$aGharahkhani, Puya$$b7
000141709 7001_ $$aWebb, Penelope M$$b8
000141709 7001_ $$aMacGregor, Stuart$$b9
000141709 7001_ $$aConsortium, Ovarian Cancer Association$$b10$$eCollaboration Author
000141709 7001_ $$aOng, Jue-Sheng$$b11
000141709 7001_ $$aHwang, Liang-Dar$$b12
000141709 7001_ $$aCuellar-Partida, Gabriel$$b13
000141709 7001_ $$aBryne, Enda$$b14
000141709 7001_ $$aFasching, Peter A$$b15
000141709 7001_ $$aHein, Alexander$$b16
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000141709 7001_ $$aBeckmann, Matthias W$$b18
000141709 7001_ $$aLambrechts, Diether$$b19
000141709 7001_ $$aVan Nieuwenhuysen, Els$$b20
000141709 7001_ $$aVergote, Ignace$$b21
000141709 7001_ $$aVanderstichele, Adriaan$$b22
000141709 7001_ $$aSwerdlow, Anthony J$$b23
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000141709 7001_ $$aRodriguez-Antona, Cristina$$b31
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000141709 773__ $$0PERI:(DE-600)1494592-7$$a10.1093/ije/dyx236$$gVol. 47, no. 2, p. 450 - 459$$n2$$p450 - 459$$tInternational journal of epidemiology$$v47$$x1464-3685$$y2018
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