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@ARTICLE{Ong:141709,
      author       = {J.-S. Ong and L.-D. Hwang and G. Cuellar-Partida and N. G.
                      Martin and G. Chenevix-Trench and M. C. J. Quinn and M. C.
                      Cornelis and P. Gharahkhani and P. M. Webb and S. MacGregor
                      and J.-S. Ong and L.-D. Hwang and G. Cuellar-Partida and E.
                      Bryne and P. A. Fasching and A. Hein and S. Burghaus and M.
                      W. Beckmann and D. Lambrechts and E. Van Nieuwenhuysen and
                      I. Vergote and A. Vanderstichele and A. J. Swerdlow and M.
                      Jones and N. Orr and M. Schoemaker and D. V. Edwards and J.
                      Brenton and J. Benítez and M. J. García and C.
                      Rodriguez-Antona and M. A. Rossing and R.
                      Turzanski-Fortner$^*$ and E. Riboli and J. Chang-Claude$^*$
                      and U. Eilber and S. Wang-Gohrke and D. Yannoukakos and M.
                      T. Goodman and N. Bogdanova and T. Dörk and M. Duerst and
                      P. Hillemanns and I. B. Runnebaum and N. Antonenkova and R.
                      Butzow and H. Nevanlinna and L. M. Pelttari and R. P.
                      Edwards and J. L. Kelley and F. Modugno and K. B. Moysich
                      and R. B. Ness and R. Cannioto and F. Heitz and B. Karlan
                      and H. Olsson and S. K. Kjaer and A. Jensen and G. G. Giles
                      and F. Bruinsma and M. A. T. Hildebrandt and D. Liang and X.
                      Wu and L. Le Marchand and V. W. Setiawan and J. B. Permuth
                      and M. Bisogna and F. Dao and D. A. Levine and D. W. Cramer
                      and K. L. Terry and S. S. Tworoger and M. Stampfer and W.
                      Willet and S. Missmer and L. Bjorge and R. K. Kopperud and
                      K. Bischof and L. C. V. Thomsen and L. A. Kiemeney and L. F.
                      Massuger and T. Pejovic and A. Brooks-Wilson and S. H. Olson
                      and V. McGuire and J. H. Rothstein and W. Sieh and A. S.
                      Whittemore and L. S. Cook and N. D. Le and C. B. Gilks and
                      J. Gronwald and A. Jakubowska and J. Lubiński and T. Kluz
                      and N. Wentzensen and L. Brinton and B. Trabert and J.
                      Lissowska and E. Høgdall and C. K. Høgdall and D. P.
                      Sandler and A. Wolk and J. P. Tyrer and H. Song and D.
                      Eccles and I. Campbell and R. Glasspool and I. McNeish and
                      J. Paul and N. Siddiqui and R. Sutphen and J. R. McLaughlin
                      and C. Phelan and H. Anton-Culver and A. Ziogas and T. May
                      and S. A. Gayther and A. Gentry-Maharaj and U. Menon and S.
                      J. Ramus and A. H. Wu and D. Huntsman and A. deFazio and A.
                      Dansonka-Mieszkowska and J. Kupryjanczyk and J.
                      Moes-Sosnowska and L. M. Szafron and J. M. Cunningham and S.
                      J. Winham and H. A. Risch and E. L. Goode and J. M.
                      Schildkraut and C. L. Pearce and A. Berchuck and P. D. P.
                      Pharoah and N. G. Martin and G. Chenevix-Trench and M. C. J.
                      Quinn and M. C. Cornelis and P. Gharahkhani and P. M. Webb
                      and S. MacGregor},
      collaboration = {O. C. A. Consortium},
      title        = {{A}ssessment of moderate coffee consumption and risk of
                      epithelial ovarian cancer: a {M}endelian randomization
                      study.},
      journal      = {International journal of epidemiology},
      volume       = {47},
      number       = {2},
      issn         = {1464-3685},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2018-01980},
      pages        = {450 - 459},
      year         = {2018},
      abstract     = {Coffee consumption has been shown to be associated with
                      various health outcomes in observational studies. However,
                      evidence for its association with epithelial ovarian cancer
                      (EOC) is inconsistent and it is unclear whether these
                      associations are causal.We used single nucleotide
                      polymorphisms associated with (i) coffee and (ii) caffeine
                      consumption to perform Mendelian randomization (MR) on EOC
                      risk. We conducted a two-sample MR using genetic data on
                      44 062 individuals of European ancestry from the Ovarian
                      Cancer Association Consortium (OCAC), and combined
                      instrumental variable estimates using a Wald-type ratio
                      estimator.For all EOC cases, the causal odds ratio (COR) for
                      genetically predicted consumption of one additional cup of
                      coffee per day was 0.92 $[95\%$ confidence interval (CI):
                      0.79, 1.06]. The COR was 0.90 $(95\%$ CI: 0.73, 1.10) for
                      high-grade serous EOC. The COR for genetically predicted
                      consumption of an additional 80 mg caffeine was 1.01
                      $(95\%$ CI: 0.92, 1.11) for all EOC cases and 0.90 $(95\%$
                      CI: 0.73, 1.10) for high-grade serous cases.We found no
                      evidence indicative of a strong association between EOC risk
                      and genetically predicted coffee or caffeine levels.
                      However, our estimates were not statistically inconsistent
                      with earlier observational studies and we were unable to
                      rule out small protective associations.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29186515},
      pmc          = {pmc:PMC6186013},
      doi          = {10.1093/ije/dyx236},
      url          = {https://inrepo02.dkfz.de/record/141709},
}