%0 Journal Article
%A Kröger, Janine
%A Meidtner, Karina
%A Stefan, Norbert
%A Guevara, Marcela
%A Kerrison, Nicola D
%A Ardanaz, Eva
%A Aune, Dagfinn
%A Boeing, Heiner
%A Dorronsoro, Miren
%A Dow, Courtney
%A Fagherazzi, Guy
%A Franks, Paul W
%A Freisling, Heinz
%A Gunter, Marc J
%A Huerta, José María
%A Kaaks, Rudolf
%A Key, Timothy J
%A Khaw, Kay Tee
%A Krogh, Vittorio
%A Kühn, Tilman
%A Mancini, Francesca Romana
%A Mattiello, Amalia
%A Nilsson, Peter M
%A Olsen, Anja
%A Overvad, Kim
%A Palli, Domenico
%A Quirós, J Ramón
%A Rolandsson, Olov
%A Sacerdote, Carlotta
%A Sala, Núria
%A Salamanca-Fernández, Elena
%A Sluijs, Ivonne
%A Spijkerman, Annemieke M W
%A Tjonneland, Anne
%A Tsilidis, Konstantinos K
%A Tumino, Rosario
%A van der Schouw, Yvonne T
%A Forouhi, Nita G
%A Sharp, Stephen J
%A Langenberg, Claudia
%A Riboli, Elio
%A Schulze, Matthias B
%A Wareham, Nicholas J
%T Circulating Fetuin-A and Risk of Type 2 Diabetes: A Mendelian Randomization Analysis.
%J Diabetes
%V 67
%N 6
%@ 1939-327X
%C Alexandria, Va
%I Assoc.
%M DKFZ-2018-01981
%P 1200 - 1205
%D 2018
%X Fetuin-A, a hepatic-origin protein, is strongly positively associated with risk of type 2 diabetes in human observational studies, but it is unknown whether this association is causal. We aimed to study the potential causal relation of circulating fetuin-A to risk of type 2 diabetes in a Mendelian randomization study with single nucleotide polymorphisms located in the fetuin-A-encoding AHSG gene. We used data from eight European countries of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study including 10,020 incident cases. Plasma fetuin-A concentration was measured in a subset of 965 subcohort participants and 654 case subjects. A genetic score of the AHSG single nucleotide polymorphisms was strongly associated with fetuin-A (28
%K AHSG protein, human (NLM Chemicals)
%K Biomarkers (NLM Chemicals)
%K alpha-2-HS-Glycoprotein (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29523632
%R 10.2337/db17-1268
%U https://inrepo02.dkfz.de/record/141710