TY  - JOUR
AU  - Kröger, Janine
AU  - Meidtner, Karina
AU  - Stefan, Norbert
AU  - Guevara, Marcela
AU  - Kerrison, Nicola D
AU  - Ardanaz, Eva
AU  - Aune, Dagfinn
AU  - Boeing, Heiner
AU  - Dorronsoro, Miren
AU  - Dow, Courtney
AU  - Fagherazzi, Guy
AU  - Franks, Paul W
AU  - Freisling, Heinz
AU  - Gunter, Marc J
AU  - Huerta, José María
AU  - Kaaks, Rudolf
AU  - Key, Timothy J
AU  - Khaw, Kay Tee
AU  - Krogh, Vittorio
AU  - Kühn, Tilman
AU  - Mancini, Francesca Romana
AU  - Mattiello, Amalia
AU  - Nilsson, Peter M
AU  - Olsen, Anja
AU  - Overvad, Kim
AU  - Palli, Domenico
AU  - Quirós, J Ramón
AU  - Rolandsson, Olov
AU  - Sacerdote, Carlotta
AU  - Sala, Núria
AU  - Salamanca-Fernández, Elena
AU  - Sluijs, Ivonne
AU  - Spijkerman, Annemieke M W
AU  - Tjonneland, Anne
AU  - Tsilidis, Konstantinos K
AU  - Tumino, Rosario
AU  - van der Schouw, Yvonne T
AU  - Forouhi, Nita G
AU  - Sharp, Stephen J
AU  - Langenberg, Claudia
AU  - Riboli, Elio
AU  - Schulze, Matthias B
AU  - Wareham, Nicholas J
TI  - Circulating Fetuin-A and Risk of Type 2 Diabetes: A Mendelian Randomization Analysis.
JO  - Diabetes
VL  - 67
IS  - 6
SN  - 1939-327X
CY  - Alexandria, Va
PB  - Assoc.
M1  - DKFZ-2018-01981
SP  - 1200 - 1205
PY  - 2018
AB  - Fetuin-A, a hepatic-origin protein, is strongly positively associated with risk of type 2 diabetes in human observational studies, but it is unknown whether this association is causal. We aimed to study the potential causal relation of circulating fetuin-A to risk of type 2 diabetes in a Mendelian randomization study with single nucleotide polymorphisms located in the fetuin-A-encoding AHSG gene. We used data from eight European countries of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study including 10,020 incident cases. Plasma fetuin-A concentration was measured in a subset of 965 subcohort participants and 654 case subjects. A genetic score of the AHSG single nucleotide polymorphisms was strongly associated with fetuin-A (28
KW  - AHSG protein, human (NLM Chemicals)
KW  - Biomarkers (NLM Chemicals)
KW  - alpha-2-HS-Glycoprotein (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:29523632
DO  - DOI:10.2337/db17-1268
UR  - https://inrepo02.dkfz.de/record/141710
ER  -