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| 001 | 141710 | ||
| 005 | 20240229111724.0 | ||
| 024 | 7 | _ | |a 10.2337/db17-1268 |2 doi |
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| 024 | 7 | _ | |a 0012-1797 |2 ISSN |
| 024 | 7 | _ | |a 1939-327X |2 ISSN |
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| 037 | _ | _ | |a DKFZ-2018-01981 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Kröger, Janine |0 0000-0002-7496-3665 |b 0 |
| 245 | _ | _ | |a Circulating Fetuin-A and Risk of Type 2 Diabetes: A Mendelian Randomization Analysis. |
| 260 | _ | _ | |a Alexandria, Va |c 2018 |b Assoc. |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1550485204_708 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Fetuin-A, a hepatic-origin protein, is strongly positively associated with risk of type 2 diabetes in human observational studies, but it is unknown whether this association is causal. We aimed to study the potential causal relation of circulating fetuin-A to risk of type 2 diabetes in a Mendelian randomization study with single nucleotide polymorphisms located in the fetuin-A-encoding AHSG gene. We used data from eight European countries of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study including 10,020 incident cases. Plasma fetuin-A concentration was measured in a subset of 965 subcohort participants and 654 case subjects. A genetic score of the AHSG single nucleotide polymorphisms was strongly associated with fetuin-A (28% explained variation). Using the genetic score as instrumental variable of fetuin-A, we observed no significant association of a 50 µg/mL higher fetuin-A concentration with diabetes risk (hazard ratio 1.02 [95% CI 0.97, 1.07]). Combining our results with those from the DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) consortium (12,171 case subjects) also did not suggest a clear significant relation of fetuin-A with diabetes risk. In conclusion, although there is mechanistic evidence for an effect of fetuin-A on insulin sensitivity and secretion, this study does not support a strong, relevant relationship between circulating fetuin-A and diabetes risk in the general population. |
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| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a AHSG protein, human |2 NLM Chemicals |
| 650 | _ | 7 | |a Biomarkers |2 NLM Chemicals |
| 650 | _ | 7 | |a alpha-2-HS-Glycoprotein |2 NLM Chemicals |
| 700 | 1 | _ | |a Meidtner, Karina |b 1 |
| 700 | 1 | _ | |a Stefan, Norbert |0 0000-0002-2186-9595 |b 2 |
| 700 | 1 | _ | |a Guevara, Marcela |b 3 |
| 700 | 1 | _ | |a Kerrison, Nicola D |b 4 |
| 700 | 1 | _ | |a Ardanaz, Eva |b 5 |
| 700 | 1 | _ | |a Aune, Dagfinn |b 6 |
| 700 | 1 | _ | |a Boeing, Heiner |b 7 |
| 700 | 1 | _ | |a Dorronsoro, Miren |b 8 |
| 700 | 1 | _ | |a Dow, Courtney |b 9 |
| 700 | 1 | _ | |a Fagherazzi, Guy |0 0000-0001-5033-5966 |b 10 |
| 700 | 1 | _ | |a Franks, Paul W |0 0000-0002-0520-7604 |b 11 |
| 700 | 1 | _ | |a Freisling, Heinz |b 12 |
| 700 | 1 | _ | |a Gunter, Marc J |b 13 |
| 700 | 1 | _ | |a Huerta, José María |b 14 |
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| 700 | 1 | _ | |a Key, Timothy J |b 16 |
| 700 | 1 | _ | |a Khaw, Kay Tee |b 17 |
| 700 | 1 | _ | |a Krogh, Vittorio |b 18 |
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| 700 | 1 | _ | |a Mancini, Francesca Romana |b 20 |
| 700 | 1 | _ | |a Mattiello, Amalia |b 21 |
| 700 | 1 | _ | |a Nilsson, Peter M |b 22 |
| 700 | 1 | _ | |a Olsen, Anja |b 23 |
| 700 | 1 | _ | |a Overvad, Kim |b 24 |
| 700 | 1 | _ | |a Palli, Domenico |b 25 |
| 700 | 1 | _ | |a Quirós, J Ramón |b 26 |
| 700 | 1 | _ | |a Rolandsson, Olov |b 27 |
| 700 | 1 | _ | |a Sacerdote, Carlotta |b 28 |
| 700 | 1 | _ | |a Sala, Núria |b 29 |
| 700 | 1 | _ | |a Salamanca-Fernández, Elena |b 30 |
| 700 | 1 | _ | |a Sluijs, Ivonne |b 31 |
| 700 | 1 | _ | |a Spijkerman, Annemieke M W |b 32 |
| 700 | 1 | _ | |a Tjonneland, Anne |b 33 |
| 700 | 1 | _ | |a Tsilidis, Konstantinos K |b 34 |
| 700 | 1 | _ | |a Tumino, Rosario |b 35 |
| 700 | 1 | _ | |a van der Schouw, Yvonne T |b 36 |
| 700 | 1 | _ | |a Forouhi, Nita G |0 0000-0002-5041-248X |b 37 |
| 700 | 1 | _ | |a Sharp, Stephen J |b 38 |
| 700 | 1 | _ | |a Langenberg, Claudia |b 39 |
| 700 | 1 | _ | |a Riboli, Elio |b 40 |
| 700 | 1 | _ | |a Schulze, Matthias B |0 0000-0002-0830-5277 |b 41 |
| 700 | 1 | _ | |a Wareham, Nicholas J |b 42 |
| 773 | _ | _ | |a 10.2337/db17-1268 |g Vol. 67, no. 6, p. 1200 - 1205 |0 PERI:(DE-600)1501252-9 |n 6 |p 1200 - 1205 |t Diabetes |v 67 |y 2018 |x 1939-327X |
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