TY  - JOUR
AU  - Xuan, Yang
AU  - Bobak, Martin
AU  - Anusruti, Ankita
AU  - Jansen, Eugène H J M
AU  - Pająk, Andrzej
AU  - Tamosiunas, Abdonas
AU  - Saum, Kai-Uwe
AU  - Holleczek, Bernd
AU  - Gao, Xin
AU  - Brenner, Hermann
AU  - Schöttker, Ben
TI  - Association of serum markers of oxidative stress with myocardial infarction and stroke: pooled results from four large European cohort studies.
JO  - European journal of epidemiology
VL  - 34
IS  - 5
SN  - 1573-7284
CY  - Dordrecht [u.a.]
PB  - Springer Science + Business Media B.V.
M1  - DKFZ-2018-02006
SP  - 471-481
PY  - 2019
AB  - Oxidative stress contributes to endothelial dysfunction and is involved in the pathogenesis of myocardial infarction (MI) and stroke. However, associations of biomarkers of oxidative stress with MI and stroke have not yet been addressed in large cohort studies. A nested case-control design was applied in four population-based cohort studies from Germany, Czech Republic, Poland and Lithuania. Derivatives of reactive oxygen metabolites (d-ROMs) levels, as a proxy for the reactive oxygen species burden, and total thiol levels (TTL), as a proxy for the reductive capacity, were measured in baseline serum samples of 476 incident MI cases and 454 incident stroke cases as well as five controls per case individually matched by study center, age and sex. Statistical analyses were conducted with multi-variable adjusted conditional logistic regression models. d-ROMs levels were associated with both MI (odds ratio (OR), 1.21 [95
LB  - PUB:(DE-HGF)16
C6  - pmid:30406496
DO  - DOI:10.1007/s10654-018-0457-x
UR  - https://inrepo02.dkfz.de/record/141737
ER  -