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@ARTICLE{Xuan:141737,
      author       = {Y. Xuan$^*$ and M. Bobak and A. Anusruti$^*$ and E. H. J.
                      M. Jansen and A. Pająk and A. Tamosiunas and K.-U. Saum$^*$
                      and B. Holleczek and X. Gao$^*$ and H. Brenner$^*$ and B.
                      Schöttker$^*$},
      title        = {{A}ssociation of serum markers of oxidative stress with
                      myocardial infarction and stroke: pooled results from four
                      large {E}uropean cohort studies.},
      journal      = {European journal of epidemiology},
      volume       = {34},
      number       = {5},
      issn         = {1573-7284},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V.},
      reportid     = {DKFZ-2018-02006},
      pages        = {471-481},
      year         = {2019},
      abstract     = {Oxidative stress contributes to endothelial dysfunction and
                      is involved in the pathogenesis of myocardial infarction
                      (MI) and stroke. However, associations of biomarkers of
                      oxidative stress with MI and stroke have not yet been
                      addressed in large cohort studies. A nested case-control
                      design was applied in four population-based cohort studies
                      from Germany, Czech Republic, Poland and Lithuania.
                      Derivatives of reactive oxygen metabolites (d-ROMs) levels,
                      as a proxy for the reactive oxygen species burden, and total
                      thiol levels (TTL), as a proxy for the reductive capacity,
                      were measured in baseline serum samples of 476 incident MI
                      cases and 454 incident stroke cases as well as five controls
                      per case individually matched by study center, age and sex.
                      Statistical analyses were conducted with multi-variable
                      adjusted conditional logistic regression models. d-ROMs
                      levels were associated with both MI (odds ratio (OR), 1.21
                      $[95\%$ confidence interval (CI) 1.05-1.40] for 100 Carr
                      units increase) and stroke (OR, 1.17 $[95\%$ CI 1.01-1.35]
                      for 100 Carr units increase). TTL were only associated with
                      stroke incidence (OR, 0.79 $[95\%$ CI 0.63-0.99] for
                      quartiles 2-4 vs. quartile 1). The observed relationships
                      were stronger with fatal than with non-fatal endpoints;
                      association of TTL with fatal MI was statistically
                      significant (OR, 0.69 $[95\%$ CI 0.51-0.93] for
                      100 μmol/L-increase). This pooled analysis of four large
                      population-based cohorts suggests an important contribution
                      of an imbalanced redox system to the etiology of mainly
                      fatal MI and stroke events.},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {323 - Metabolic Dysfunction as Risk Factor (POF3-323)},
      pid          = {G:(DE-HGF)POF3-323},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30406496},
      doi          = {10.1007/s10654-018-0457-x},
      url          = {https://inrepo02.dkfz.de/record/141737},
}