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000141765 1001_ $$aBrenner, Darren R$$b0
000141765 245__ $$aAlcohol consumption and lung cancer risk: A pooled analysis from the International Lung Cancer Consortium and the SYNERGY study.
000141765 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2019
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000141765 520__ $$aThere is inadequate evidence to determine whether there is an effect of alcohol consumption on lung cancer risk. We conducted a pooled analysis of data from the International Lung Cancer Consortium and the SYNERGY study to investigate this possible association by type of beverage with adjustment for other potential confounders.Twenty one case-control studies and one cohort study with alcohol-intake data obtained from questionnaires were included in this pooled analysis (19,149 cases and 362,340 controls). Adjusted odds ratios (OR) or hazard ratios (HR) with corresponding 95% confidence intervals (CI) were estimated for each measure of alcohol consumption. Effect estimates were combined using random or fixed-effects models where appropriate. Associations were examined for overall lung cancer and by histological type.We observed an inverse association between overall risk of lung cancer and consumption of alcoholic beverages compared to non-drinkers, but the association was not monotonic. The lowest risk was observed for persons who consumed 10-19.9 g/day ethanol (OR vs. non-drinkers = 0.78; 95% CI: 0.67, 0.91), where 1 drink is approximately 12-15 g. This J-shaped association was most prominent for squamous cell carcinoma (SCC). The association with all lung cancer varied little by type of alcoholic beverage, but there were notable differences for SCC. We observed an association with beer intake (OR for ≥20 g/day vs nondrinker = 1.42; 95% CI: 1.06, 1.90).Whether the non-monotonic associations we observed or the positive association between beer drinking and squamous cell carcinoma reflect real effects await future analyses and insights about possible biological mechanisms.
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000141765 7001_ $$aFehringer, Gord$$b1
000141765 7001_ $$aZhang, Zuo-Feng$$b2
000141765 7001_ $$aLee, Yuan-Chin Amy$$b3
000141765 7001_ $$aMeyers, Travis$$b4
000141765 7001_ $$aMatsuo, Keitaro$$b5
000141765 7001_ $$aIto, Hidemi$$b6
000141765 7001_ $$aVineis, Paolo$$b7
000141765 7001_ $$aStucker, Isabelle$$b8
000141765 7001_ $$aBoffetta, Paolo$$b9
000141765 7001_ $$aBrennan, Paul$$b10
000141765 7001_ $$aChristiani, David C$$b11
000141765 7001_ $$aDiao, Nancy$$b12
000141765 7001_ $$aHong, Yun-Chul$$b13
000141765 7001_ $$aLandi, Maria T$$b14
000141765 7001_ $$aMorgenstern, Hal$$b15
000141765 7001_ $$aSchwartz, Ann G$$b16
000141765 7001_ $$aRennert, Gad$$b17
000141765 7001_ $$aSaliba, Walid$$b18
000141765 7001_ $$aMcLaughlin, John R$$b19
000141765 7001_ $$aHarris, Curtis C$$b20
000141765 7001_ $$aOrlow, Irene$$b21
000141765 7001_ $$aBarros Dios, Juan M$$b22
000141765 7001_ $$aRuano Raviña, Alberto$$b23
000141765 7001_ $$aSiemiatycki, Jack$$b24
000141765 7001_ $$aKoushik, Anita$$b25
000141765 7001_ $$aCote, Michele$$b26
000141765 7001_ $$aLazarus, Philip$$b27
000141765 7001_ $$aFernandez-Tardon, Guillermo$$b28
000141765 7001_ $$aTardon, Adonina$$b29
000141765 7001_ $$aLe Marchand, Loïc$$b30
000141765 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b31$$udkfz
000141765 7001_ $$0P:(DE-He78)97343bbd9545a4b87574e74329dabfd1$$aSaum, Kai-Uwe$$b32$$udkfz
000141765 7001_ $$aDuell, Eric J$$b33
000141765 7001_ $$aAndrew, Angeline S$$b34
000141765 7001_ $$aConsonni, Dario$$b35
000141765 7001_ $$aOlsson, Ann$$b36
000141765 7001_ $$aHung, Rayjean J$$b37
000141765 7001_ $$aStraif, Kurt$$b38
000141765 773__ $$0PERI:(DE-600)2498032-8$$a10.1016/j.canep.2018.10.006$$gVol. 58, p. 25 - 32$$p25 - 32$$tCancer epidemiology$$v58$$x1877-7821$$y2019
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