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@ARTICLE{Brenner:141765,
      author       = {D. R. Brenner and G. Fehringer and Z.-F. Zhang and Y. A.
                      Lee and T. Meyers and K. Matsuo and H. Ito and P. Vineis and
                      I. Stucker and P. Boffetta and P. Brennan and D. C.
                      Christiani and N. Diao and Y.-C. Hong and M. T. Landi and H.
                      Morgenstern and A. G. Schwartz and G. Rennert and W. Saliba
                      and J. R. McLaughlin and C. C. Harris and I. Orlow and J. M.
                      Barros Dios and A. Ruano Raviña and J. Siemiatycki and A.
                      Koushik and M. Cote and P. Lazarus and G. Fernandez-Tardon
                      and A. Tardon and L. Le Marchand and H. Brenner$^*$ and
                      K.-U. Saum$^*$ and E. J. Duell and A. S. Andrew and D.
                      Consonni and A. Olsson and R. J. Hung and K. Straif},
      title        = {{A}lcohol consumption and lung cancer risk: {A} pooled
                      analysis from the {I}nternational {L}ung {C}ancer
                      {C}onsortium and the {SYNERGY} study.},
      journal      = {Cancer epidemiology},
      volume       = {58},
      issn         = {1877-7821},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2018-02034},
      pages        = {25 - 32},
      year         = {2019},
      abstract     = {There is inadequate evidence to determine whether there is
                      an effect of alcohol consumption on lung cancer risk. We
                      conducted a pooled analysis of data from the International
                      Lung Cancer Consortium and the SYNERGY study to investigate
                      this possible association by type of beverage with
                      adjustment for other potential confounders.Twenty one
                      case-control studies and one cohort study with
                      alcohol-intake data obtained from questionnaires were
                      included in this pooled analysis (19,149 cases and 362,340
                      controls). Adjusted odds ratios (OR) or hazard ratios (HR)
                      with corresponding $95\%$ confidence intervals (CI) were
                      estimated for each measure of alcohol consumption. Effect
                      estimates were combined using random or fixed-effects models
                      where appropriate. Associations were examined for overall
                      lung cancer and by histological type.We observed an inverse
                      association between overall risk of lung cancer and
                      consumption of alcoholic beverages compared to non-drinkers,
                      but the association was not monotonic. The lowest risk was
                      observed for persons who consumed 10-19.9 g/day ethanol
                      (OR vs. non-drinkers = 0.78; $95\%$ CI: 0.67, 0.91),
                      where 1 drink is approximately 12-15 g. This J-shaped
                      association was most prominent for squamous cell carcinoma
                      (SCC). The association with all lung cancer varied little by
                      type of alcoholic beverage, but there were notable
                      differences for SCC. We observed an association with beer
                      intake (OR for ≥20 g/day vs nondrinker = 1.42;
                      $95\%$ CI: 1.06, 1.90).Whether the non-monotonic
                      associations we observed or the positive association between
                      beer drinking and squamous cell carcinoma reflect real
                      effects await future analyses and insights about possible
                      biological mechanisms.},
      cin          = {C070 / C120 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30445228},
      doi          = {10.1016/j.canep.2018.10.006},
      url          = {https://inrepo02.dkfz.de/record/141765},
}