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@ARTICLE{Koerber:141816,
      author       = {S. A. Koerber and B. Seither and A. Slynko$^*$ and M. F.
                      Haefner and D. Krug and J. Liermann and S. Adeberg and K.
                      Herfarth and J. Debus and F. Sterzing},
      title        = {{C}hemoradiation in female patients with anal cancer:
                      {P}atient-reported outcome of acute and chronic side
                      effects.},
      journal      = {Tumori journal},
      volume       = {105},
      number       = {2},
      issn         = {2038-2529},
      address      = {Thousand Oaks, Calif.},
      publisher    = {Sage},
      reportid     = {DKFZ-2018-02084},
      pages        = {174-180},
      year         = {2019},
      abstract     = {We evaluated acute and chronic side effects of 3D conformal
                      radiotherapy (3D-CRT) and intensity-modulated radiation
                      therapy (IMRT) in female patients with anal carcinoma and
                      accessed correlations between dosimetric parameters and the
                      considered toxicities.For 70 women with anal cancer treated
                      at our department, acute and chronic side effects and
                      quality of life (QoL) were evaluated with questionnaires
                      using the Common Terminology Criteria for Adverse Events
                      (CTCAE v. 4.0.) and Late Effects in Normal Tissue,
                      Subjective, Objective Management and Analytic Scales
                      (LentSoma) before, during, and after the
                      treatment.Forty-seven out of 70 $(67\%)$ patients completed
                      the questionnaire and were enrolled in the study. Only poor
                      urinary stream, loss of pubic hair during chemoradiation,
                      and chronic vaginal dryness were observed more frequently in
                      the 3D-CRT group compared to the IMRT group (univariable
                      logistic regression p = .032, p = .04, p = .049,
                      respectively). After the treatment, $43\%$ in the 3D-CRT
                      group and $29\%$ in the IMRT group reported a severe loss of
                      QoL. A higher proportion among the patients receiving a
                      genital V20 $⩾35\%$ showed grade 1-3 side effects such as
                      chronic dyspareunia ( p = .035; Fisher exact test).Our
                      results suggest that the use of IMRT decreases acute and
                      chronic adverse effects although reduced QoL also occurred
                      in the IMRT group. These effects are likely to be
                      underreported in retrospective studies using
                      physician-reported outcome measures.},
      cin          = {C060},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30484384},
      doi          = {10.1177/0300891618811273},
      url          = {https://inrepo02.dkfz.de/record/141816},
}