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@ARTICLE{Maida:141826,
      author       = {A. Maida$^*$ and A. Zota$^*$ and A. Vegiopoulos$^*$ and S.
                      Appak-Baskoy$^*$ and H. Augustin$^*$ and M. Heikenwalder$^*$
                      and S. Herzig$^*$ and A. J. Rose$^*$},
      title        = {{D}ietary protein dilution limits dyslipidemia in obesity
                      through {FGF}21-driven fatty acid clearance.},
      journal      = {The journal of nutritional biochemistry},
      volume       = {57},
      issn         = {0955-2863},
      address      = {New York, NY [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2018-02094},
      pages        = {189 - 196},
      year         = {2018},
      abstract     = {Recent studies have demonstrated that dietary protein
                      dilution (PD) can promote metabolic inefficiency and improve
                      glucose metabolism. However, whether PD can promote other
                      aspects of metabolic health, such as improve systemic lipid
                      metabolism, and mechanisms therein remains unknown. Mouse
                      models of obesity, such as high-fat-diet-fed C57Bl/6 N mice,
                      and New Zealand Obese mice were fed normal (i.e., $20\%P)$
                      and protein-dilute (i.e., $5\%EP)$ diets. FGF21-/- and
                      Cd36-/- and corresponding littermate +/+ controls were also
                      studied to examine gene-diet interactions. Here, we show
                      that chronic PD retards the development of
                      hypertrigylceridemia and fatty liver in obesity and that
                      this relies on the induction of the hepatokine fibroblast
                      growth factor 21 (FGF21). Furthermore, PD greatly enhances
                      systemic lipid homeostasis, the mechanisms by which include
                      FGF21-stimulated, and cluster of differentiation 36 (CD36)
                      mediated, fatty acid clearance by oxidative tissues, such as
                      heart and brown adipose tissue. Taken together, our
                      preclinical studies demonstrate a novel nutritional
                      strategy, as well as highlight a role for FGF21-stimulated
                      systemic lipid metabolism, in combating obesity-related
                      dyslipidemia.},
      cin          = {A170 / A171 / A190 / F180},
      ddc          = {640},
      cid          = {I:(DE-He78)A170-20160331 / I:(DE-He78)A171-20160331 /
                      I:(DE-He78)A190-20160331 / I:(DE-He78)F180-20160331},
      pnm          = {323 - Metabolic Dysfunction as Risk Factor (POF3-323)},
      pid          = {G:(DE-HGF)POF3-323},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29751292},
      doi          = {10.1016/j.jnutbio.2018.03.027},
      url          = {https://inrepo02.dkfz.de/record/141826},
}