%0 Journal Article
%A Chen, Chen
%A Stock, Christian
%A Hoffmeister, Michael
%A Brenner, Hermann
%T How long does it take until the effects of endoscopic screening on colorectal cancer mortality are fully disclosed?: a Markov model study.
%J International journal of cancer
%V 143
%N 11
%@ 0020-7136
%C Bognor Regis
%I Wiley-Liss
%M DKFZ-2018-02122
%P 2718 - 2724
%D 2018
%X A recent randomized trial has suggested persisting protection from colorectal cancer (CRC) incidence and mortality of a single flexible sigmoidoscopy for up to 17 years and possibly beyond. We performed a simulation study to explore the time course and magnitude of protection provided by screening colonoscopy against CRC death over 25 years. Using data from the German national screening colonoscopy registry, a multistate Markov model was set up based on the adenoma-carcinoma pathway to estimate cumulative CRC mortality when different proportions of the population have a single screening colonoscopy at age 55, or two screening colonoscopies at ages 55 and 65. Cumulative CRC mortality continuously increased with age and reached 2.6 and 1.7
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29978478
%R 10.1002/ijc.31716
%U https://inrepo02.dkfz.de/record/141865