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@ARTICLE{Ittermann:141872,
      author       = {T. Ittermann and N. Werner and W. Lieb and B. Merz and U.
                      Nöthlings and A. Kluttig and D. Tiller and K.-H.
                      Greiser$^*$ and S. Vogt and B. Thorand and A. Peters and H.
                      Völzke and M. Dörr and S. Schipf and M. R. P. Markus},
      title        = {{C}hanges in fat mass and fat-free-mass are associated with
                      incident hypertension in four population-based studies from
                      {G}ermany.},
      journal      = {International journal of cardiology},
      volume       = {274},
      issn         = {0167-5273},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2018-02129},
      pages        = {372 - 377},
      year         = {2019},
      abstract     = {We estimated the association of changes in body weight,
                      waist circumference (WC), fat mass (FM) and fat-free mass
                      (FFM) with changes in blood pressure and incident
                      hypertension using data from four German population-based
                      studies.We analyzed data from 4467 participants, aged 21 to
                      82 years not taking antihypertensive medication and not
                      having type 2 diabetes mellitus or a history of myocardial
                      infarction at baseline and follow-up, from four
                      population-based studies conducted in Germany. Body weight,
                      WC, and blood pressure were measured at baseline and
                      follow-up (median follow-up of the single studies 4 to
                      7 years). FM and FFM were calculated based on
                      height-weight models derived from bioelectrical impedance
                      studies. Hypertension was defined as systolic blood
                      pressure ≥ 140 mmHg or diastolic blood
                      pressure ≥ 90 mmHg. Confounder-adjusted linear and
                      logistic regressions were used to associate changes in
                      anthropometric markers with changes in blood pressure,
                      incident hypertension, and incident normalization of blood
                      pressure.In a pooled dataset including all four studies,
                      increments in body weight, WC, FM, and FFM were
                      statistically significantly associated with incident
                      hypertension and changes in systolic and diastolic blood
                      pressure over time. Decreases in body weight, FM, and FFM
                      were significantly associated with incident normalization of
                      blood pressure.Our data suggests that the well-established
                      association between obesity and blood pressure levels might
                      be more related to body composition rather than to total
                      body weight per se. Our findings indicate that gaining or
                      losing FFM has substantial impact on the development or
                      reversion of hypertension.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {323 - Metabolic Dysfunction as Risk Factor (POF3-323)},
      pid          = {G:(DE-HGF)POF3-323},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30217425},
      doi          = {10.1016/j.ijcard.2018.09.035},
      url          = {https://inrepo02.dkfz.de/record/141872},
}