TY  - JOUR
AU  - Jiang, Yuming
AU  - Xie, Jingjing
AU  - Han, Zhen
AU  - Liu, Wei
AU  - Xi, Sujuan
AU  - Huang, Lei
AU  - Huang, Weicai
AU  - Lin, Tian
AU  - Zhao, Liying
AU  - Hu, Yanfeng
AU  - Yu, Jiang
AU  - Zhang, Qi
AU  - Li, Tuanjie
AU  - Cai, Shirong
AU  - Li, Guoxin
TI  - Immunomarker Support Vector Machine Classifier for Prediction of Gastric Cancer Survival and Adjuvant Chemotherapeutic Benefit.
JO  - Clinical cancer research
VL  - 24
IS  - 22
SN  - 1557-3265
CY  - Philadelphia, Pa. [u.a.]
PB  - AACR
M1  - DKFZ-2018-02130
SP  - 5574 - 5584
PY  - 2018
AB  - Purpose: Current tumor-node-metastasis (TNM) staging system cannot provide adequate information for prediction of prognosis and chemotherapeutic benefits. We constructed a classifier to predict prognosis and identify a subset of patients who can benefit from adjuvant chemotherapy.Experimental Design: We detected expression of 15 immunohistochemistry (IHC) features in tumors from 251 gastric cancer (GC) patients and evaluated the association of their expression level with overall survival (OS) and disease-free survival (DFS). Then, integrating multiple clinicopathologic features and IHC features, we used support vector machine (SVM)-based methods to develop a prognostic classifier (GC-SVM classifier) with features. Further validation of the GC-SVM classifier was performed in two validation cohorts of 535 patients.Results: The GC-SVM classifier integrated patient sex, carcinoembryonic antigen, lymph node metastasis, and the protein expression level of eight features, including CD3invasive margin (IM), CD3center of tumor (CT), CD8IM, CD45ROCT, CD57IM, CD66bIM, CD68CT, and CD34. Significant differences were found between the high- and low-GC-SVM patients in 5-year OS and DFS in training and validation cohorts. Multivariate analysis revealed that the GC-SVM classifier was an independent prognostic factor. The classifier had higher predictive accuracy for OS and DFS than TNM stage and can complement the prognostic value of the TNM staging system. Further analysis revealed that stage II and III GC patients with high-GC-SVM were likely to benefit from adjuvant chemotherapy.Conclusions: The newly developed GC-SVM classifier was a powerful predictor of OS and DFS. Moreover, the GC-SVM classifier could predict which patients with stage II and III GC benefit from adjuvant chemotherapy. Clin Cancer Res; 24(22); 5574-84. ©2018 AACR.
LB  - PUB:(DE-HGF)16
C6  - pmid:30042208
DO  - DOI:10.1158/1078-0432.CCR-18-0848
UR  - https://inrepo02.dkfz.de/record/141873
ER  -