TY  - JOUR
AU  - Schübel, Ruth
AU  - Nattenmüller, Johanna
AU  - Sookthai, Disorn
AU  - Nonnenmacher, Tobias
AU  - Graf, Mirja E
AU  - Riedl, Lena
AU  - Schlett, Christopher L
AU  - von Stackelberg, Oyunbileg
AU  - Johnson, Theron Scot
AU  - Nabers, Diana
AU  - Kirsten, Romy
AU  - Kratz, Mario
AU  - Kauczor, Hans-Ulrich
AU  - Ulrich, Cornelia M
AU  - Kaaks, Rudolf
AU  - Kühn, Tilman
TI  - Effects of intermittent and continuous calorie restriction on body weight and metabolism over 50 wk: a randomized controlled trial.
JO  - The American journal of clinical nutrition
VL  - 108
IS  - 5
SN  - 1938-3207
CY  - Oxford
PB  - Oxford University Press
M1  - DKFZ-2018-02164
SP  - 933 - 945
PY  - 2018
AB  - Although preliminary evidence suggests that intermittent calorie restriction (ICR) exerts stronger effects on metabolic parameters, which may link obesity and major chronic diseases, compared with continuous calorie restriction (CCR), there is a lack of well-powered intervention studies.We conducted a randomized controlled trial to test whether ICR, operationalized as the '5:2 diet,' has stronger effects on adipose tissue gene expression, anthropometric and body composition measures, and circulating metabolic biomarkers than CCR and a control regimen.One hundred and fifty overweight and obese nonsmokers [body mass index (kg/m2) ≥25 to <40, 50
LB  - PUB:(DE-HGF)16
C6  - pmid:30475957
DO  - DOI:10.1093/ajcn/nqy196
UR  - https://inrepo02.dkfz.de/record/141907
ER  -