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@ARTICLE{Ridley:141908,
      author       = {B. Ridley and A. Nagel$^*$ and M. Bydder and A. Maarouf and
                      J.-P. Stellmann and S. Gherib and J. Verneuil and P. Viout
                      and M. Guye and J.-P. Ranjeva and W. Zaaraoui},
      title        = {{D}istribution of brain sodium long and short relaxation
                      times and concentrations: a multi-echo ultra-high field
                      23{N}a {MRI} study.},
      journal      = {Scientific reports},
      volume       = {8},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DKFZ-2018-02165},
      pages        = {4357},
      year         = {2018},
      abstract     = {Sodium (23Na) MRI proffers the possibility of novel
                      information for neurological research but also particular
                      challenges. Uncertainty can arise in in vivo 23Na estimates
                      from signal losses given the rapidity of T2* decay due to
                      biexponential relaxation with both short (T2*short) and long
                      (T2*long) components. We build on previous work by
                      characterising the decay curve directly via multi-echo
                      imaging at 7 T in 13 controls with the requisite number,
                      distribution and range to assess the distribution of both in
                      vivo T2*short and T2*long and in variation between grey and
                      white matter, and subregions. By modelling the relationship
                      between signal and reference concentration and applying it
                      to in vivo 23Na-MRI signal, 23Na concentrations and apparent
                      transverse relaxation times of different brain regions were
                      measured for the first time. Relaxation components and
                      concentrations differed substantially between regions of
                      differing tissue composition, suggesting sensitivity of
                      multi-echo 23Na-MRI toward features of tissue composition.
                      As such, these results raise the prospect of multi-echo
                      23Na-MRI as an adjunct source of information on biochemical
                      mechanisms in both physiological and pathophysiological
                      states.},
      cin          = {E020},
      ddc          = {600},
      cid          = {I:(DE-He78)E020-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29531255},
      pmc          = {pmc:PMC5847519},
      doi          = {10.1038/s41598-018-22711-0},
      url          = {https://inrepo02.dkfz.de/record/141908},
}