TY  - JOUR
AU  - Bochtler, Tilmann
AU  - Merz, Maximilian
AU  - Hielscher, Thomas
AU  - Granzow, Martin
AU  - Hoffmann, Korbinian
AU  - Krämer, Alwin
AU  - Raab, Marc-Steffen
AU  - Hillengass, Jens
AU  - Seckinger, Anja
AU  - Kimmich, Christoph
AU  - Dittrich, Tobias
AU  - Müller-Tidow, Carsten
AU  - Hose, Dirk
AU  - Goldschmidt, Hartmut
AU  - Hegenbart, Ute
AU  - Jauch, Anna
AU  - Schönland, Stefan O
TI  - Cytogenetic intraclonal heterogeneity of plasma cell dyscrasia in AL amyloidosis as compared with multiple myeloma.
JO  - Blood advances
VL  - 2
IS  - 20
SN  - 2473-9537
CY  - Washington, DC
PB  - American Society of Hematology
M1  - DKFZ-2018-02172
SP  - 2607 - 2618
PY  - 2018
AB  - Analysis of intraclonal heterogeneity has yielded insights into the clonal evolution of hematologic malignancies. We compared the clonal and subclonal compositions of the underlying plasma cell dyscrasia in 544 systemic light chain amyloidosis (PC-AL) patients with 519 patients with monoclonal gammopathy of undetermined significance (MGUS), smoldering multiple myeloma (SMM), or symptomatic MM; ie, PC-non-AL patients). Using interphase fluorescence in situ hybridization, subclones were stringently defined as clone size below two thirds of the largest clone and an absolute difference of ≥30
LB  - PUB:(DE-HGF)16
C6  - pmid:30327369
C2  - pmc:PMC6199662
DO  - DOI:10.1182/bloodadvances.2018023200
UR  - https://inrepo02.dkfz.de/record/141915
ER  -