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@ARTICLE{Kriegsmann:141916,
      author       = {K. Kriegsmann and H. Löffler$^*$ and V. Eckstein and R.
                      Schulz and S. Kräker and U. Braun and T. Luft and U.
                      Hegenbart and S. Schönland and P. Dreger and A. Krämer$^*$
                      and A. D. Ho and C. Müller-Tidow and M. Hundemer},
      title        = {{CD}7 is expressed on a subset of normal {CD}34-positive
                      myeloid precursors.},
      journal      = {European journal of haematology},
      volume       = {101},
      number       = {3},
      issn         = {0902-4441},
      address      = {Oxford},
      publisher    = {Wiley-Blackwell},
      reportid     = {DKFZ-2018-02173},
      pages        = {318 - 325},
      year         = {2018},
      abstract     = {To improve monitoring of myeloid neoplasms by flow
                      cytometry-based minimal residual disease (MRD) analysis, we
                      analyzed the significance of leukemia-associated
                      immunophenotype (LAIP) markers in 44 patients.In a pilot
                      study cohort, peripheral blood or bone marrow samples from
                      13 patients with myeloid neoplasms and one case of B
                      lymphoblastic leukemia in complete hematologic remission
                      after allogeneic bone marrow or stem cell transplantation
                      were subjected to selection for leukemia-specific phenotypes
                      by fluorescence-activated cell sorting using individual
                      marker combinations, followed by PCR-based chimerism
                      analysis.The feasibility of this method could be
                      demonstrated, with selection being successful in 12 cases,
                      including two cases where mixed chimerism was found
                      exclusively in sorted cells. Interestingly, four specimens
                      displayed full donor chimerism in cells expressing the
                      presumably aberrant combination CD34+ /CD7+ . Further
                      analyses, including assessment of an independent cohort of
                      25 patients not affected by neoplastic bone marrow
                      infiltration, revealed that normal myeloid precursors
                      usually include a population coexpressing CD34, CD13, CD33,
                      and CD7.We conclude that the combination CD34+ /CD7+ might
                      not be suitable as an LAIP for MRD diagnostics and that a
                      subset of normal myeloid precursors in the bone marrow
                      expresses CD7.},
      cin          = {G330},
      ddc          = {610},
      cid          = {I:(DE-He78)G330-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29797671},
      doi          = {10.1111/ejh.13100},
      url          = {https://inrepo02.dkfz.de/record/141916},
}