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000141968 1001_ $$00000-0002-5869-7344$$aAckermann, Sandra$$b0
000141968 245__ $$aA mechanistic classification of clinical phenotypes in neuroblastoma.
000141968 260__ $$aCambridge, Mass.$$bMoses King$$c2018
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000141968 520__ $$aNeuroblastoma is a pediatric tumor of the sympathetic nervous system. Its clinical course ranges from spontaneous tumor regression to fatal progression. To investigate the molecular features of the divergent tumor subtypes, we performed genome sequencing on 416 pretreatment neuroblastomas and assessed telomere maintenance mechanisms in 208 of these tumors. We found that patients whose tumors lacked telomere maintenance mechanisms had an excellent prognosis, whereas the prognosis of patients whose tumors harbored telomere maintenance mechanisms was substantially worse. Survival rates were lowest for neuroblastoma patients whose tumors harbored telomere maintenance mechanisms in combination with RAS and/or p53 pathway mutations. Spontaneous tumor regression occurred both in the presence and absence of these mutations in patients with telomere maintenance-negative tumors. On the basis of these data, we propose a mechanistic classification of neuroblastoma that may benefit the clinical management of patients.
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000141968 7001_ $$00000-0003-4129-890X$$aHero, Barbara$$b2
000141968 7001_ $$aWelte, Anne$$b3
000141968 7001_ $$aKahlert, Yvonne$$b4
000141968 7001_ $$aRoderwieser, Andrea$$b5
000141968 7001_ $$aBartenhagen, Christoph$$b6
000141968 7001_ $$aWalter, Esther$$b7
000141968 7001_ $$aGecht, Judith$$b8
000141968 7001_ $$00000-0002-1195-7399$$aKerschke, Laura$$b9
000141968 7001_ $$aVolland, Ruth$$b10
000141968 7001_ $$00000-0002-4891-0885$$aMenon, Roopika$$b11
000141968 7001_ $$00000-0003-1714-9509$$aHeuckmann, Johannes M$$b12
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000141968 7001_ $$aAltmüller, Janine$$b17
000141968 7001_ $$00000-0002-7228-428X$$aNürnberg, Peter$$b18
000141968 7001_ $$aLefever, Steve$$b19
000141968 7001_ $$00000-0003-0213-1322$$ade Wilde, Bram$$b20
000141968 7001_ $$aSand, Frederik$$b21
000141968 7001_ $$aIkram, Fakhera$$b22
000141968 7001_ $$aRosswog, Carolina$$b23
000141968 7001_ $$aFischer, Janina$$b24
000141968 7001_ $$aTheissen, Jessica$$b25
000141968 7001_ $$00000-0003-4784-6516$$aHertwig, Falk$$b26
000141968 7001_ $$aSinghi, Aatur D$$b27
000141968 7001_ $$aSimon, Thorsten$$b28
000141968 7001_ $$aVogel, Wenzel$$b29
000141968 7001_ $$aPerner, Sven$$b30
000141968 7001_ $$aKrug, Barbara$$b31
000141968 7001_ $$aSchmidt, Matthias$$b32
000141968 7001_ $$00000-0002-8536-6065$$aRahmann, Sven$$b33
000141968 7001_ $$aAchter, Viktor$$b34
000141968 7001_ $$aLang, Ulrich$$b35
000141968 7001_ $$aVokuhl, Christian$$b36
000141968 7001_ $$aOrtmann, Monika$$b37
000141968 7001_ $$aBüttner, Reinhard$$b38
000141968 7001_ $$00000-0003-3476-8184$$aEggert, Angelika$$b39
000141968 7001_ $$aSpeleman, Frank$$b40
000141968 7001_ $$aO'Sullivan, Roderick J$$b41
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000141968 7001_ $$aVandesompele, Jo$$b44
000141968 7001_ $$00000-0001-7670-7529$$aSchramm, Alexander$$b45
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000141968 7001_ $$aPeifer, Martin$$b48
000141968 7001_ $$aFischer, Matthias$$b49
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