% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Ackermann:141968,
      author       = {S. Ackermann and M. Cartolano and B. Hero and A. Welte and
                      Y. Kahlert and A. Roderwieser and C. Bartenhagen and E.
                      Walter and J. Gecht and L. Kerschke and R. Volland and R.
                      Menon and J. M. Heuckmann and M. Gartlgruber$^*$ and S.
                      Hartlieb$^*$ and K.-O. Henrich$^*$ and K. Okonechnikov$^*$
                      and J. Altmüller and P. Nürnberg and S. Lefever and B. de
                      Wilde and F. Sand and F. Ikram and C. Rosswog and J. Fischer
                      and J. Theissen and F. Hertwig$^*$ and A. D. Singhi and T.
                      Simon and W. Vogel and S. Perner and B. Krug and M. Schmidt
                      and S. Rahmann and V. Achter and U. Lang and C. Vokuhl and
                      M. Ortmann and R. Büttner and A. Eggert and F. Speleman and
                      R. J. O'Sullivan and R. K. Thomas$^*$ and F. Berthold and J.
                      Vandesompele and A. Schramm and F. Westermann$^*$ and J.
                      Schulte$^*$ and M. Peifer and M. Fischer},
      title        = {{A} mechanistic classification of clinical phenotypes in
                      neuroblastoma.},
      journal      = {Science},
      volume       = {362},
      number       = {6419},
      issn         = {0036-8075},
      address      = {Cambridge, Mass.},
      publisher    = {Moses King},
      reportid     = {DKFZ-2018-02198},
      pages        = {1165 - 1170},
      year         = {2018},
      abstract     = {Neuroblastoma is a pediatric tumor of the sympathetic
                      nervous system. Its clinical course ranges from spontaneous
                      tumor regression to fatal progression. To investigate the
                      molecular features of the divergent tumor subtypes, we
                      performed genome sequencing on 416 pretreatment
                      neuroblastomas and assessed telomere maintenance mechanisms
                      in 208 of these tumors. We found that patients whose tumors
                      lacked telomere maintenance mechanisms had an excellent
                      prognosis, whereas the prognosis of patients whose tumors
                      harbored telomere maintenance mechanisms was substantially
                      worse. Survival rates were lowest for neuroblastoma patients
                      whose tumors harbored telomere maintenance mechanisms in
                      combination with RAS and/or p53 pathway mutations.
                      Spontaneous tumor regression occurred both in the presence
                      and absence of these mutations in patients with telomere
                      maintenance-negative tumors. On the basis of these data, we
                      propose a mechanistic classification of neuroblastoma that
                      may benefit the clinical management of patients.},
      cin          = {B062 / B087 / L101},
      ddc          = {500},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)B087-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30523111},
      doi          = {10.1126/science.aat6768},
      url          = {https://inrepo02.dkfz.de/record/141968},
}