guest ::
| Home > Publications database > A mechanistic classification of clinical phenotypes in neuroblastoma. > print |
| Home > Publications database > A mechanistic classification of clinical phenotypes in neuroblastoma. > print |
| 001 | 141968 | ||
| 005 | 20240229105136.0 | ||
| 024 | 7 | _ | |a 10.1126/science.aat6768 |2 doi |
| 024 | 7 | _ | |a pmid:30523111 |2 pmid |
| 024 | 7 | _ | |a 0036-8075 |2 ISSN |
| 024 | 7 | _ | |a 1095-9203 |2 ISSN |
| 024 | 7 | _ | |a 1947-8062 |2 ISSN |
| 024 | 7 | _ | |a altmetric:52293890 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2018-02198 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 500 |
| 100 | 1 | _ | |a Ackermann, Sandra |0 0000-0002-5869-7344 |b 0 |
| 245 | _ | _ | |a A mechanistic classification of clinical phenotypes in neuroblastoma. |
| 260 | _ | _ | |a Cambridge, Mass. |c 2018 |b Moses King |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1680515722_22927 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Neuroblastoma is a pediatric tumor of the sympathetic nervous system. Its clinical course ranges from spontaneous tumor regression to fatal progression. To investigate the molecular features of the divergent tumor subtypes, we performed genome sequencing on 416 pretreatment neuroblastomas and assessed telomere maintenance mechanisms in 208 of these tumors. We found that patients whose tumors lacked telomere maintenance mechanisms had an excellent prognosis, whereas the prognosis of patients whose tumors harbored telomere maintenance mechanisms was substantially worse. Survival rates were lowest for neuroblastoma patients whose tumors harbored telomere maintenance mechanisms in combination with RAS and/or p53 pathway mutations. Spontaneous tumor regression occurred both in the presence and absence of these mutations in patients with telomere maintenance-negative tumors. On the basis of these data, we propose a mechanistic classification of neuroblastoma that may benefit the clinical management of patients. |
| 536 | _ | _ | |a 312 - Functional and structural genomics (POF3-312) |0 G:(DE-HGF)POF3-312 |c POF3-312 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 700 | 1 | _ | |a Cartolano, Maria |b 1 |
| 700 | 1 | _ | |a Hero, Barbara |0 0000-0003-4129-890X |b 2 |
| 700 | 1 | _ | |a Welte, Anne |b 3 |
| 700 | 1 | _ | |a Kahlert, Yvonne |b 4 |
| 700 | 1 | _ | |a Roderwieser, Andrea |b 5 |
| 700 | 1 | _ | |a Bartenhagen, Christoph |b 6 |
| 700 | 1 | _ | |a Walter, Esther |b 7 |
| 700 | 1 | _ | |a Gecht, Judith |b 8 |
| 700 | 1 | _ | |a Kerschke, Laura |0 0000-0002-1195-7399 |b 9 |
| 700 | 1 | _ | |a Volland, Ruth |b 10 |
| 700 | 1 | _ | |a Menon, Roopika |0 0000-0002-4891-0885 |b 11 |
| 700 | 1 | _ | |a Heuckmann, Johannes M |0 0000-0003-1714-9509 |b 12 |
| 700 | 1 | _ | |a Gartlgruber, Moritz |0 P:(DE-He78)5190aa0a28a0d3d663954c463290e4c1 |b 13 |
| 700 | 1 | _ | |a Hartlieb, Sabine |0 P:(DE-He78)311fe8118b7563b455ba84e94fccb3a8 |b 14 |
| 700 | 1 | _ | |a Henrich, Kai-Oliver |0 P:(DE-He78)a579ca2567736066534409e732b31c91 |b 15 |
| 700 | 1 | _ | |a Okonechnikov, Konstantin |0 P:(DE-He78)34b3639de467b2c700920d7cbc3d2110 |b 16 |
| 700 | 1 | _ | |a Altmüller, Janine |b 17 |
| 700 | 1 | _ | |a Nürnberg, Peter |0 0000-0002-7228-428X |b 18 |
| 700 | 1 | _ | |a Lefever, Steve |b 19 |
| 700 | 1 | _ | |a de Wilde, Bram |0 0000-0003-0213-1322 |b 20 |
| 700 | 1 | _ | |a Sand, Frederik |b 21 |
| 700 | 1 | _ | |a Ikram, Fakhera |b 22 |
| 700 | 1 | _ | |a Rosswog, Carolina |b 23 |
| 700 | 1 | _ | |a Fischer, Janina |b 24 |
| 700 | 1 | _ | |a Theissen, Jessica |b 25 |
| 700 | 1 | _ | |a Hertwig, Falk |0 0000-0003-4784-6516 |b 26 |
| 700 | 1 | _ | |a Singhi, Aatur D |b 27 |
| 700 | 1 | _ | |a Simon, Thorsten |b 28 |
| 700 | 1 | _ | |a Vogel, Wenzel |b 29 |
| 700 | 1 | _ | |a Perner, Sven |b 30 |
| 700 | 1 | _ | |a Krug, Barbara |b 31 |
| 700 | 1 | _ | |a Schmidt, Matthias |b 32 |
| 700 | 1 | _ | |a Rahmann, Sven |0 0000-0002-8536-6065 |b 33 |
| 700 | 1 | _ | |a Achter, Viktor |b 34 |
| 700 | 1 | _ | |a Lang, Ulrich |b 35 |
| 700 | 1 | _ | |a Vokuhl, Christian |b 36 |
| 700 | 1 | _ | |a Ortmann, Monika |b 37 |
| 700 | 1 | _ | |a Büttner, Reinhard |b 38 |
| 700 | 1 | _ | |a Eggert, Angelika |0 0000-0003-3476-8184 |b 39 |
| 700 | 1 | _ | |a Speleman, Frank |b 40 |
| 700 | 1 | _ | |a O'Sullivan, Roderick J |b 41 |
| 700 | 1 | _ | |a Thomas, Roman K |0 P:(DE-HGF)0 |b 42 |
| 700 | 1 | _ | |a Berthold, Frank |b 43 |
| 700 | 1 | _ | |a Vandesompele, Jo |b 44 |
| 700 | 1 | _ | |a Schramm, Alexander |0 0000-0001-7670-7529 |b 45 |
| 700 | 1 | _ | |a Westermann, Frank |0 P:(DE-He78)91f32735ee876c579d63c05a7f4778dd |b 46 |e Last author |
| 700 | 1 | _ | |a Schulte, Johannes |0 P:(DE-He78)91317a47fc8532e3daf0d0b362c2a27e |b 47 |e Last author |
| 700 | 1 | _ | |a Peifer, Martin |b 48 |
| 700 | 1 | _ | |a Fischer, Matthias |b 49 |
| 773 | _ | _ | |a 10.1126/science.aat6768 |g Vol. 362, no. 6419, p. 1165 - 1170 |0 PERI:(DE-600)2066996-3 |n 6419 |p 1165 - 1170 |t Science |v 362 |y 2018 |x 0036-8075 |
| 909 | C | O | |p VDB |o oai:inrepo02.dkfz.de:141968 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 13 |6 P:(DE-He78)5190aa0a28a0d3d663954c463290e4c1 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 14 |6 P:(DE-He78)311fe8118b7563b455ba84e94fccb3a8 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 15 |6 P:(DE-He78)a579ca2567736066534409e732b31c91 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 16 |6 P:(DE-He78)34b3639de467b2c700920d7cbc3d2110 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 26 |6 0000-0003-4784-6516 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 42 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 46 |6 P:(DE-He78)91f32735ee876c579d63c05a7f4778dd |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 47 |6 P:(DE-He78)91317a47fc8532e3daf0d0b362c2a27e |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Krebsforschung |1 G:(DE-HGF)POF3-310 |0 G:(DE-HGF)POF3-312 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Functional and structural genomics |x 0 |
| 914 | 1 | _ | |y 2018 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |
| 915 | _ | _ | |a National-Konsortium |0 StatID:(DE-HGF)0430 |2 StatID |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b SCIENCE : 2017 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1060 |2 StatID |b Current Contents - Agriculture, Biology and Environmental Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1150 |2 StatID |b Current Contents - Physical, Chemical and Earth Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1040 |2 StatID |b Zoological Record |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a IF >= 40 |0 StatID:(DE-HGF)9940 |2 StatID |b SCIENCE : 2017 |
| 920 | 1 | _ | |0 I:(DE-He78)B062-20160331 |k B062 |l B062 Pädiatrische Neuroonkologie |x 0 |
| 920 | 1 | _ | |0 I:(DE-He78)B087-20160331 |k B087 |l B087 Neuroblastom Genomik |x 1 |
| 920 | 1 | _ | |0 I:(DE-He78)L101-20160331 |k L101 |l DKTK Heidelberg |x 2 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)B062-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B087-20160331 |
| 980 | _ | _ | |a I:(DE-He78)L101-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|