% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Aron:141978,
      author       = {R. Aron and P. Pellegrini and E. Green$^*$ and D. C.
                      Maddison and K. Opoku-Nsiah and J. S. Wong and A. C. Daub
                      and F. Giorgini and S. Finkbeiner},
      title        = {{D}eubiquitinase {U}sp12 functions noncatalytically to
                      induce autophagy and confer neuroprotection in models of
                      {H}untington's disease.},
      journal      = {Nature Communications},
      volume       = {9},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2018-02208},
      pages        = {3191},
      year         = {2018},
      abstract     = {Huntington's disease is a progressive neurodegenerative
                      disorder caused by polyglutamine-expanded mutant huntingtin
                      (mHTT). Here, we show that the deubiquitinase Usp12 rescues
                      mHTT-mediated neurodegeneration in Huntington's disease
                      rodent and patient-derived human neurons, and in Drosophila.
                      The neuroprotective role of Usp12 may be specific amongst
                      related deubiquitinases, as the closely related homolog
                      Usp46 does not suppress mHTT-mediated toxicity.
                      Mechanistically, we identify Usp12 as a potent inducer of
                      neuronal autophagy. Usp12 overexpression accelerates
                      autophagic flux and induces an approximately sixfold
                      increase in autophagic structures as determined by
                      ultrastructural analyses, while suppression of endogenous
                      Usp12 slows autophagy. Surprisingly, the catalytic activity
                      of Usp12 is not required to protect against
                      neurodegeneration or induce autophagy. These findings
                      identify the deubiquitinase Usp12 as a regulator of neuronal
                      proteostasis and mHTT-mediated neurodegeneration.},
      cin          = {G160},
      ddc          = {500},
      cid          = {I:(DE-He78)G160-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30266909},
      pmc          = {pmc:PMC6162324},
      doi          = {10.1038/s41467-018-05653-z},
      url          = {https://inrepo02.dkfz.de/record/141978},
}