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@ARTICLE{Boll:141987,
      author       = {S. Boll and A. C. Almeida de Minas$^*$ and A.
                      Raftogianni$^*$ and S. C. Herpertz and V. Grinevich$^*$},
      title        = {{O}xytocin and {P}ain {P}erception: {F}rom {A}nimal
                      {M}odels to {H}uman {R}esearch.},
      journal      = {Neuroscience},
      volume       = {387},
      issn         = {0306-4522},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2018-02217},
      pages        = {149 - 161},
      year         = {2018},
      abstract     = {An accumulating body of evidence suggests that the
                      hypothalamic neuropeptide oxytocin (OT) has a modulatory
                      effect on pain processing. Particularly strong evidence
                      comes from animal models. Here, we review recent advances in
                      animal research on the analgesic effects of OT and discuss
                      possible target sites of OT within descending and ascending
                      pain pathways in the brain. In addition to the spinal cord
                      being a direct target of the neuropeptide, OT has also been
                      shown to modulate the neuronal activity of limbic and
                      cortical brain regions, which play a major role in the
                      cognitive and emotional processing of pain. Human studies
                      investigating the influence of OT on pain perception are
                      less numerous and have revealed less consistent results. The
                      human literature is therefore scanned thoroughly and
                      different approaches to study the effects of OT on pain
                      perception in humans are discussed. Moreover, we also
                      address how OT might alleviate pain by influencing
                      socio-emotional components in humans. We conclude that
                      further investigating specific OT and OT-sensitive circuits,
                      which modulate pain processing especially in primates, will
                      improve our understanding of OT-analgesic effects. In human
                      research, the increased use of neuroimaging and autonomic
                      measures might help to bridge the gap to animal studies.},
      subtyp        = {Review Article},
      cin          = {V078},
      ddc          = {610},
      cid          = {I:(DE-He78)V078-20160331},
      pnm          = {319H - Addenda (POF3-319H)},
      pid          = {G:(DE-HGF)POF3-319H},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28965836},
      doi          = {10.1016/j.neuroscience.2017.09.041},
      url          = {https://inrepo02.dkfz.de/record/141987},
}