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@ARTICLE{GonzalezDuque:142038,
      author       = {S. Gonzalez-Duque and M. E. Azoury and M. L. Colli and G.
                      Afonso and J.-V. Turatsinze and L. Nigi and A. I. Lalanne
                      and G. Sebastiani and A. Carré and S. Pinto$^*$ and S.
                      Culina and N. Corcos and M. Bugliani and P. Marchetti and M.
                      Armanet and M. Diedisheim and B. Kyewski$^*$ and L. M.
                      Steinmetz and S. Buus and S. You and D. Dubois-Laforgue and
                      E. Larger and J.-P. Beressi and G. Bruno and F. Dotta and R.
                      Scharfmann and D. L. Eizirik and Y. Verdier and J. Vinh and
                      R. Mallone},
      title        = {{C}onventional and {N}eo-antigenic {P}eptides {P}resented
                      by β {C}ells {A}re {T}argeted by {C}irculating {N}aïve
                      {CD}8+ {T} {C}ells in {T}ype 1 {D}iabetic and {H}ealthy
                      {D}onors.},
      journal      = {Cell metabolism},
      volume       = {28},
      number       = {6},
      issn         = {1550-4131},
      address      = {Cambridge, Mass.},
      publisher    = {Cell Press},
      reportid     = {DKFZ-2018-02268},
      pages        = {946 - 960.e6},
      year         = {2018},
      abstract     = {Although CD8+ T-cell-mediated autoimmune β cell
                      destruction occurs in type 1 diabetes (T1D), the target
                      epitopes processed and presented by β cells are unknown. To
                      identify them, we combined peptidomics and transcriptomics
                      strategies. Inflammatory cytokines increased peptide
                      presentation in vitro, paralleling upregulation of human
                      leukocyte antigen (HLA) class I expression. Peptide sources
                      featured several insulin granule proteins and all known β
                      cell antigens, barring islet-specific glucose-6-phosphatase
                      catalytic subunit-related protein. Preproinsulin yielded
                      HLA-A2-restricted epitopes previously described.
                      Secretogranin V and its mRNA splice isoform SCG5-009,
                      proconvertase-2, urocortin-3, the insulin gene enhancer
                      protein ISL-1, and an islet amyloid polypeptide
                      transpeptidation product emerged as antigens processed into
                      HLA-A2-restricted epitopes, which, as those already
                      described, were recognized by circulating naive CD8+
                      T cells in T1D and healthy donors and by
                      pancreas-infiltrating cells in T1D donors. This peptidome
                      opens new avenues to understand antigen processing by β
                      cells and for the development of T cell biomarkers and
                      tolerogenic vaccination strategies.},
      cin          = {D090},
      ddc          = {570},
      cid          = {I:(DE-He78)D090-20160331},
      pnm          = {314 - Tumor immunology (POF3-314)},
      pid          = {G:(DE-HGF)POF3-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30078552},
      doi          = {10.1016/j.cmet.2018.07.007},
      url          = {https://inrepo02.dkfz.de/record/142038},
}