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| Home > Publications database > Conventional and Neo-antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors. > print |
| Home > Publications database > Conventional and Neo-antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors. > print |
| 001 | 142038 | ||
| 005 | 20240229105140.0 | ||
| 024 | 7 | _ | |a 10.1016/j.cmet.2018.07.007 |2 doi |
| 024 | 7 | _ | |a pmid:30078552 |2 pmid |
| 024 | 7 | _ | |a 1550-4131 |2 ISSN |
| 024 | 7 | _ | |a 1932-7420 |2 ISSN |
| 024 | 7 | _ | |a altmetric:45907655 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2018-02268 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Gonzalez-Duque, Sergio |b 0 |
| 245 | _ | _ | |a Conventional and Neo-antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors. |
| 260 | _ | _ | |a Cambridge, Mass. |c 2018 |b Cell Press |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1549885941_1055 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Although CD8+ T-cell-mediated autoimmune β cell destruction occurs in type 1 diabetes (T1D), the target epitopes processed and presented by β cells are unknown. To identify them, we combined peptidomics and transcriptomics strategies. Inflammatory cytokines increased peptide presentation in vitro, paralleling upregulation of human leukocyte antigen (HLA) class I expression. Peptide sources featured several insulin granule proteins and all known β cell antigens, barring islet-specific glucose-6-phosphatase catalytic subunit-related protein. Preproinsulin yielded HLA-A2-restricted epitopes previously described. Secretogranin V and its mRNA splice isoform SCG5-009, proconvertase-2, urocortin-3, the insulin gene enhancer protein ISL-1, and an islet amyloid polypeptide transpeptidation product emerged as antigens processed into HLA-A2-restricted epitopes, which, as those already described, were recognized by circulating naive CD8+ T cells in T1D and healthy donors and by pancreas-infiltrating cells in T1D donors. This peptidome opens new avenues to understand antigen processing by β cells and for the development of T cell biomarkers and tolerogenic vaccination strategies. |
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| 700 | 1 | _ | |a Azoury, Marie Eliane |b 1 |
| 700 | 1 | _ | |a Colli, Maikel L |b 2 |
| 700 | 1 | _ | |a Afonso, Georgia |b 3 |
| 700 | 1 | _ | |a Turatsinze, Jean-Valery |b 4 |
| 700 | 1 | _ | |a Nigi, Laura |b 5 |
| 700 | 1 | _ | |a Lalanne, Ana Ines |b 6 |
| 700 | 1 | _ | |a Sebastiani, Guido |b 7 |
| 700 | 1 | _ | |a Carré, Alexia |b 8 |
| 700 | 1 | _ | |a Pinto, Sheena |0 P:(DE-He78)d2f9dbffa7b9a979f9bc4d81e769497e |b 9 |u dkfz |
| 700 | 1 | _ | |a Culina, Slobodan |b 10 |
| 700 | 1 | _ | |a Corcos, Noémie |b 11 |
| 700 | 1 | _ | |a Bugliani, Marco |b 12 |
| 700 | 1 | _ | |a Marchetti, Piero |b 13 |
| 700 | 1 | _ | |a Armanet, Mathieu |b 14 |
| 700 | 1 | _ | |a Diedisheim, Marc |b 15 |
| 700 | 1 | _ | |a Kyewski, Bruno |0 P:(DE-He78)08a57258198dcedd8ff8ac7eef40341a |b 16 |u dkfz |
| 700 | 1 | _ | |a Steinmetz, Lars M |b 17 |
| 700 | 1 | _ | |a Buus, Søren |b 18 |
| 700 | 1 | _ | |a You, Sylvaine |b 19 |
| 700 | 1 | _ | |a Dubois-Laforgue, Daniele |b 20 |
| 700 | 1 | _ | |a Larger, Etienne |b 21 |
| 700 | 1 | _ | |a Beressi, Jean-Paul |b 22 |
| 700 | 1 | _ | |a Bruno, Graziella |b 23 |
| 700 | 1 | _ | |a Dotta, Francesco |b 24 |
| 700 | 1 | _ | |a Scharfmann, Raphael |b 25 |
| 700 | 1 | _ | |a Eizirik, Decio L |b 26 |
| 700 | 1 | _ | |a Verdier, Yann |b 27 |
| 700 | 1 | _ | |a Vinh, Joelle |b 28 |
| 700 | 1 | _ | |a Mallone, Roberto |b 29 |
| 773 | _ | _ | |a 10.1016/j.cmet.2018.07.007 |g Vol. 28, no. 6, p. 946 - 960.e6 |0 PERI:(DE-600)2174469-5 |n 6 |p 946 - 960.e6 |t Cell metabolism |v 28 |y 2018 |x 1550-4131 |
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