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@ARTICLE{Ladd:142071,
      author       = {M. Ladd$^*$ and P. Bachert$^*$ and M. Meyerspeer and E.
                      Moser$^*$ and A. Nagel$^*$ and D. G. Norris and S.
                      Schmitter$^*$ and O. Speck and S. Straub$^*$ and M. Zaiss},
      title        = {{P}ros and cons of ultra-high-field {MRI}/{MRS} for human
                      application.},
      journal      = {Progress in nuclear magnetic resonance spectroscopy},
      volume       = {109},
      issn         = {0079-6565},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2018-02301},
      pages        = {1 - 50},
      year         = {2018},
      abstract     = {Magnetic resonance imaging and spectroscopic techniques are
                      widely used in humans both for clinical diagnostic
                      applications and in basic research areas such as cognitive
                      neuroimaging. In recent years, new human MR systems have
                      become available operating at static magnetic fields of
                      7 T or higher (≥300 MHz proton frequency). Imaging
                      human-sized objects at such high frequencies presents
                      several challenges including non-uniform radiofrequency
                      fields, enhanced susceptibility artifacts, and higher
                      radiofrequency energy deposition in the tissue. On the other
                      side of the scale are gains in signal-to-noise or
                      contrast-to-noise ratio that allow finer structures to be
                      visualized and smaller physiological effects to be detected.
                      This review presents an overview of some of the latest
                      methodological developments in human ultra-high field
                      MRI/MRS as well as associated clinical and scientific
                      applications. Emphasis is given to techniques that
                      particularly benefit from the changing physical
                      characteristics at high magnetic fields, including
                      susceptibility-weighted imaging and phase-contrast
                      techniques, imaging with X-nuclei, MR spectroscopy, CEST
                      imaging, as well as functional MRI. In addition, more
                      general methodological developments such as parallel
                      transmission and motion correction will be discussed that
                      are required to leverage the full potential of higher
                      magnetic fields, and an overview of relevant physiological
                      considerations of human high magnetic field exposure is
                      provided.},
      subtyp        = {Review Article},
      cin          = {E020},
      ddc          = {530},
      cid          = {I:(DE-He78)E020-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30527132},
      doi          = {10.1016/j.pnmrs.2018.06.001},
      url          = {https://inrepo02.dkfz.de/record/142071},
}