% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Mder:142085,
      author       = {L. Mäder and A. E. Blank and D. Capper$^*$ and J. Jansong
                      and P. Baumgarten and N. M. Wirsik and C. Zachskorn$^*$ and
                      J. Ehlers and M. Seifert and B. Klink and S. Liebner and S.
                      Niclou and U. Naumann and P. N. Harter$^*$ and M.
                      Mittelbronn$^*$},
      title        = {{P}ericytes/vessel-associated mural cells ({VAMC}s) are the
                      major source of key epithelial-mesenchymal transition
                      ({EMT}) factors {SLUG} and {TWIST} in human glioma.},
      journal      = {OncoTarget},
      volume       = {9},
      number       = {35},
      issn         = {1949-2553},
      address      = {[S.l.]},
      publisher    = {Impact Journals LLC},
      reportid     = {DKFZ-2018-02315},
      pages        = {24041-24053},
      year         = {2018},
      abstract     = {Epithelial-to-mesenchymal transition (EMT) is supposed to
                      be responsible for increased invasion and metastases in
                      epithelial cancer cells. The activation of EMT genes has
                      further been proposed to be important in the process of
                      malignant transformation of primary CNS tumors. Since the
                      cellular source and clinical impact of EMT factors in
                      primary CNS tumors still remain unclear, we aimed at
                      deciphering their distribution in vivo and
                      clinico-pathological relevance in human gliomas. We
                      investigated 350 glioma patients for the expression of the
                      key EMT factors SLUG and TWIST by immunohistochemistry and
                      immunofluorescence related to morpho-genetic alterations
                      such as EGFR-amplification, IDH-1 (R132H) mutation and
                      1p/19q LOH. Furthermore, transcriptional cluster and
                      survival analyses were performed. Our data illustrate that
                      SLUG and TWIST are overexpressed in gliomas showing vascular
                      proliferation such as pilocytic astrocytomas and
                      glioblastomas. EMT factors are exclusively expressed by
                      non-neoplastic pericytes/vessel-associated mural cells
                      (VAMCs). They are not associated with patient survival but
                      correlate with pericytic/VAMC genes in glioblastoma cluster
                      analysis. In summary, the upregulation of EMT genes in
                      pilocytic astrocytomas and glioblastomas reflects the level
                      of activation of pericytes/VAMCs in newly formed blood
                      vessels. Our results underscore that the negative prognostic
                      potential of the EMT signature in the group of diffuse
                      gliomas of WHO grade II-IV does most likely not derive from
                      glioma cells but rather reflects the degree of proliferating
                      mural cells thereby constituting a potential target for
                      future alternative treatment approaches.},
      cin          = {G380},
      ddc          = {610},
      cid          = {I:(DE-He78)G380-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29844871},
      pmc          = {pmc:PMC5963615},
      doi          = {10.18632/oncotarget.25275},
      url          = {https://inrepo02.dkfz.de/record/142085},
}