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@ARTICLE{Matejcic:142089,
author = {M. Matejcic and F. Lesueur and C. Biessy and A. L. Renault
and N. Mebirouk and S. Yammine and P. Keski-Rahkonen and K.
Li and B. Hémon and E. Weiderpass and V. Rebours and M. C.
Boutron-Ruault and F. Carbonnel and R. Kaaks$^*$ and V.
Katzke$^*$ and T. Kuhn$^*$ and H. Boeing and A. Trichopoulou
and D. Palli and C. Agnoli and S. Panico and R. Tumino and
C. Sacerdote and J. R. Quirós and E. J. Duell and M. Porta
and M. J. Sánchez and M. D. Chirlaque and A. Barricarte and
P. Amiano and W. Ye and P. H. Peeters and K. T. Khaw and A.
Perez-Cornago and T. J. Key and H. B. Bueno-de-Mesquita and
E. Riboli and P. Vineis and I. Romieu and M. J. Gunter and
V. Chajès},
title = {{C}irculating plasma phospholipid fatty acids and risk of
pancreatic cancer in a large {E}uropean cohort.},
journal = {International journal of cancer},
volume = {143},
number = {10},
issn = {0020-7136},
address = {Bognor Regis},
publisher = {Wiley-Liss},
reportid = {DKFZ-2018-02319},
pages = {2437 - 2448},
year = {2018},
abstract = {There are both limited and conflicting data on the role of
dietary fat and specific fatty acids in the development of
pancreatic cancer. In this study, we investigated the
association between plasma phospholipid fatty acids and
pancreatic cancer risk in the European Prospective
Investigation into Cancer and Nutrition (EPIC) cohort. The
fatty acid composition was measured by gas chromatography in
plasma samples collected at recruitment from375 incident
pancreatic cancer cases and375 matched controls.
Associations of specific fatty acids with pancreatic cancer
risk were evaluated using multivariable conditional logistic
regression models with adjustment for established pancreatic
cancer risk factors. Statistically significant inverse
associations were found between pancreatic cancer incidence
and levels of heptadecanoic acid (ORT3-T1 [odds ratio for
highest versus lowest tertile] =0.63; $95\%CI[confidence$
interval] = 0.41-0.98; ptrend = 0.036), n-3 polyunsaturated
α-linolenic acid (ORT3-T1 = 0.60; $95\%CI$ = 0.39-0.92;
ptrend = 0.02) and docosapentaenoic acid (ORT3-T1 = 0.52;
$95\%CI$ = 0.32-0.85; ptrend = 0.008). Industrial
trans-fatty acids were positively associated with pancreatic
cancer risk among men (ORT3-T1 = 3.00; $95\%CI$ = 1.13-7.99;
ptrend = 0.029), while conjugated linoleic acids were
inversely related to pancreatic cancer among women only
(ORT3-T1 = 0.37; $95\%CI$ = 0.17-0.81; ptrend = 0.008).
Among current smokers, the long-chain n-6/n-3
polyunsaturated fatty acids ratio was positively associated
with pancreatic cancer risk (ORT3-T1 = 3.40; $95\%CI$ =
1.39-8.34; ptrend = 0.007). Results were robust to a range
of sensitivity analyses. Our findings suggest that higher
circulating levels of saturated fatty acids with an odd
number of carbon atoms and n-3 polyunsaturated fatty acids
may be related to lower risk of pancreatic cancer. The
influence of some fatty acids on the development of
pancreatic cancer may be sex-specific and modulated by
smoking.},
cin = {C020},
ddc = {610},
cid = {I:(DE-He78)C020-20160331},
pnm = {313 - Cancer risk factors and prevention (POF3-313)},
pid = {G:(DE-HGF)POF3-313},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:30110135},
doi = {10.1002/ijc.31797},
url = {https://inrepo02.dkfz.de/record/142089},
}