TY  - JOUR
AU  - Paech, Daniel
AU  - Windschuh, Johannes
AU  - Oberhollenzer, Johanna
AU  - Dreher, Constantin
AU  - Sahm, Felix
AU  - Meissner, Jan-Eric
AU  - Goerke, Steffen
AU  - Schuenke, Patrick
AU  - Zaiss, Moritz
AU  - Regnery, Sebastian
AU  - Bickelhaupt, Sebastian
AU  - Bäumer, Philipp
AU  - Bendszus, Martin
AU  - Wick, Wolfgang
AU  - Unterberg, Andreas
AU  - Bachert, Peter
AU  - Ladd, Mark
AU  - Schlemmer, Heinz-Peter
AU  - Radbruch, Alexander
TI  - Assessing the predictability of IDH mutation and MGMT methylation status in glioma patients using relaxation-compensated multipool CEST MRI at 7.0 T.
JO  - Neuro-Oncology
VL  - 20
IS  - 12
SN  - 1523-5866
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2018-02333
SP  - 1661 - 1671
PY  - 2018
AB  - Early identification of prognostic superior characteristics in glioma patients such as isocitrate dehydrogenase (IDH) mutation and O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation status is of great clinical importance. The study purpose was to investigate the non-invasive predictability of IDH mutation status, MGMT promoter methylation, and differentiation of low-grade versus high-grade glioma (LGG vs HGG) in newly diagnosed patients employing relaxation-compensated multipool chemical exchange saturation transfer (CEST) MRI at 7.0 Tesla.Thirty-one patients with newly diagnosed glioma were included in this prospective study. CEST MRI was performed at a 7T whole-body scanner. Nuclear Overhauser effect (NOE) and isolated amide proton transfer (APT; downfield NOE-suppressed APT = dns-APT) CEST signals (mean value and 90th signal percentile) were quantitatively investigated in the whole tumor area with regard to predictability of IDH mutation, MGMT promoter methylation status, and differentiation of LGG versus HGG. Statistics were performed using receiver operating characteristic (ROC) and area under the curve (AUC) analysis. Results were compared with advanced MRI methods (apparent diffusion coefficient and relative cerebral blood volume ROC/AUC analysis) obtained at 3T.dns-APT CEST yielded highest AUCs in IDH mutation status prediction (dns-APTmean = 91.84
LB  - PUB:(DE-HGF)16
C6  - pmid:29733378
C2  - pmc:PMC6231210
DO  - DOI:10.1093/neuonc/noy073
UR  - https://inrepo02.dkfz.de/record/142103
ER  -