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@ARTICLE{Rutkowski:142116,
      author       = {S. Rutkowski and P. Modena and D. Williamson and K. Kerl
                      and K. Nysom and B. Pizer and U. Bartels and S. Puget and F.
                      Doz and A. Michalski and K. von Hoff and M. Chevignard and
                      S. Avula and M. J. Murray and S. Schönberger and T. Czech
                      and A. Y. N. Schouten-van Meeteren and U. Kordes and C. M.
                      Kramm and D. G. van Vuurden and E. Hulleman and G. O.
                      Janssens and G. A. Solanki and M. C. van Veelen and U.
                      Thomale and M. U. Schuhmann and C. Jones and F. Giangaspero
                      and D. Figarella-Branger and T. Pietsch and S. C. Clifford
                      and S. Pfister$^*$ and S. W. Van Gool},
      title        = {{B}iological material collection to advance translational
                      research and treatment of children with {CNS} tumours:
                      position paper from the {SIOPE} {B}rain {T}umour {G}roup.},
      journal      = {The lancet / Oncology Oncology},
      volume       = {19},
      number       = {8},
      issn         = {1470-2045},
      address      = {London},
      publisher    = {The Lancet Publ. Group},
      reportid     = {DKFZ-2018-02346},
      pages        = {e419 - e428},
      year         = {2018},
      abstract     = {Paediatric CNS tumours are the most common cause of
                      childhood cancer-related morbidity and mortality, and
                      improvements in their diagnosis and treatment are needed.
                      New genetic and epigenetic information about paediatric CNS
                      tumours is transforming the field dramatically. For most
                      paediatric CNS tumour entities, subgroups with distinct
                      biological characteristics have been identified, and these
                      characteristics are increasingly used to facilitate accurate
                      diagnoses and therapeutic recommendations. Future treatments
                      will be further tailored to specific molecular subtypes of
                      disease, specific tumour predisposition syndromes, and other
                      biological criteria. Successful biomaterial collection is a
                      key requirement for the application of contemporary
                      methodologies for the validation of candidate prognostic
                      factors, the discovery of new biomarkers, the establishment
                      of appropriate preclinical research models for targeted
                      agents, a quicker clinical implementation of precision
                      medicine, and for other therapeutic uses (eg, for
                      immunotherapies). However, deficits in organisational
                      structures and interdisciplinary cooperation are impeding
                      the collection of high-quality biomaterial from CNS tumours
                      in most centres. Practical, legal, and ethical guidelines
                      for consent, storage, material transfer, biobanking, data
                      sharing, and funding should be established by research
                      consortia and local institutions to allow optimal collection
                      of primary and subsequent tumour tissue, body fluids, and
                      normal tissue. Procedures for the collection and storage of
                      biomaterials and related data should be implemented
                      according to the individual and organisational structures of
                      the local institutions.},
      subtyp        = {Review Article},
      cin          = {B062 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)L101-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30102236},
      doi          = {10.1016/S1470-2045(18)30364-4},
      url          = {https://inrepo02.dkfz.de/record/142116},
}