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@ARTICLE{Sandhoff:142119,
      author       = {R. Sandhoff$^*$ and K. Sandhoff},
      title        = {{E}merging concepts of ganglioside metabolism.},
      journal      = {FEBS letters},
      volume       = {592},
      number       = {23},
      issn         = {1873-3468},
      address      = {Chichester},
      publisher    = {Wiley},
      reportid     = {DKFZ-2018-02349},
      pages        = {3835 - 3864},
      year         = {2018},
      abstract     = {Gangliosides (GGs) are sialic acid-containing
                      glycosphingolipids (GSLs) and major membrane components
                      enriched on cellular surfaces. Biosynthesis of mammalian GGs
                      starts at the cytosolic leaflet of endoplasmic reticulum
                      (ER) membranes with the formation of their hydrophobic
                      ceramide anchors. After intracellular ceramide transfer to
                      Golgi and trans-Golgi network (TGN) membranes, anabolism of
                      GGs, as well as of other GSLs, is catalyzed by
                      membrane-spanning glycosyltransferases (GTs) along the
                      secretory pathway. Combined activity of only a few
                      promiscuous GTs allows for the formation of
                      cell-type-specific glycolipid patterns. Following an
                      exocytotic vesicle flow to the cellular plasma membranes,
                      GGs can be modified by metabolic reactions at or near the
                      cellular surface. For degradation, GGs are endocytosed to
                      reach late endosomes and lysosomes. Whereas
                      membrane-spanning enzymes of the secretory pathway catalyze
                      GSL and GG formation, a cooperation of soluble glycosidases,
                      lipases and lipid-binding cofactors, namely the sphingolipid
                      activator proteins (SAPs), act as the main players of GG and
                      GSL catabolism at intralysosomal luminal vesicles (ILVs).},
      subtyp        = {Review Article},
      cin          = {G131},
      ddc          = {610},
      cid          = {I:(DE-He78)G131-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29802621},
      doi          = {10.1002/1873-3468.13114},
      url          = {https://inrepo02.dkfz.de/record/142119},
}