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@ARTICLE{Vollherbst:142195,
      author       = {D. F. Vollherbst and R. Otto and T. D. Do and A. von
                      Deimling$^*$ and H. U. Kauczor and M. Bendszus and C. M.
                      Sommer and M. A. Möhlenbruch},
      title        = {{E}xtra-small dual-lumen micro-balloon catheters can
                      improve endovascular embolization: an experimental in vivo
                      and in vitro study.},
      journal      = {Journal of neuroInterventional surgery},
      volume       = {10},
      number       = {11},
      issn         = {1759-8486},
      address      = {London},
      publisher    = {BMJ Journals},
      reportid     = {DKFZ-2019-00009},
      pages        = {1092 - 1096},
      year         = {2018},
      abstract     = {The embolization technique can have significant impact on
                      the success of endovascular embolization.To evaluate the
                      feasibility, embolization characteristics, and embolization
                      extent with a newly developed extra-small micro-balloon
                      catheter in an in vivo and in an in vitro embolization model
                      in comparison with standard microcatheter
                      embolizations.Twenty-eight embolization procedures were
                      performed in the porcine rete mirabile (RM) and in an in
                      vitro embolization model, using either an extra-small
                      (distal outer diameter 1.6 F) dual-lumen micro-balloon
                      catheter or a standard microcatheter. Precipitating
                      hydrophobic injectable liquid (PHIL) was used as embolic
                      agent. Procedure times, number of injections, required
                      volume of embolic agent, and embolization extent (percentage
                      of embolized RM in postinterventional X-ray scans or number
                      of filled sections of the in vitro model) were assessed.
                      Histopathological analyses were performed.Total procedure
                      time was significantly shorter (in vivo: 123 s vs 615 s
                      (medians), P=0.001; in vitro: 180 s vs 496 s (medians),
                      P=0.001), number of reflux events was significantly lower
                      (in vivo: 0 vs 9 (medians), P=0.001; in vitro: 0 vs 3
                      (medians), P=0.001), and embolization extent was
                      significantly higher (in vivo: $96.9\%$ vs $65.6\%$
                      (medians), P=0.011; in vitro: 26 vs 18 filled sections
                      (medians); P=0.041) for the micro-balloon catheter groups.
                      There was antegrade movement of the PHIL cast after balloon
                      deflation in one in vitro embolization procedure and
                      spontaneous balloon deflation with subsequent reflux in one
                      in vivo embolization procedure.Extra-small dual-lumen
                      micro-balloon catheters can improve endovascular
                      embolization in comparison with standard microcatheter
                      embolization.},
      cin          = {G380},
      ddc          = {610},
      cid          = {I:(DE-He78)G380-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29555871},
      doi          = {10.1136/neurintsurg-2018-013752},
      url          = {https://inrepo02.dkfz.de/record/142195},
}