TY  - JOUR
AU  - Witt, Hendrik
AU  - Gramatzki, Dorothee
AU  - Hentschel, Bettina
AU  - Pajtler, Kristian
AU  - Felsberg, Jörg
AU  - Schackert, Gabriele
AU  - Löffler, Markus
AU  - Capper, David
AU  - Sahm, Felix
AU  - Sill, Martin
AU  - von Deimling, Andreas
AU  - Kool, Marcel
AU  - Herrlinger, Ulrich
AU  - Westphal, Manfred
AU  - Pietsch, Torsten
AU  - Reifenberger, Guido
AU  - Pfister, Stefan
AU  - Tonn, Jörg C
AU  - Weller, Michael
TI  - DNA methylation-based classification of ependymomas in adulthood: implications for diagnosis and treatment.
JO  - Neuro-Oncology
VL  - 20
IS  - 12
SN  - 1523-5866
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2019-00021
SP  - 1616 - 1624
PY  - 2018
AB  - Ependymal tumors are glial tumors that commonly manifest in children and young adults. Their classification has remained entirely morphological until recently, and surgery and radiotherapy are the main treatment options, especially in adults. Here we sought to correlate DNA methylation profiles with clinical and pathological characteristics in the prospective cohort of the German Glioma Network.Tumors from 122 adult patients with myxopapillary ependymoma, ependymoma, anaplastic ependymoma, subependymoma, or RELA fusion-positive ependymoma classified according to the World Health Organization (WHO) 2016 were subjected to DNA methylation profiling using the Illumina HumanMethylation450 BeadChip platform. Molecular data were correlated with histologic features and clinical characteristics.At a median follow-up of 86.7 months, only 22 patients experienced progression (18.0
LB  - PUB:(DE-HGF)16
C6  - pmid:30053291
C2  - pmc:PMC6231197
DO  - DOI:10.1093/neuonc/noy118
UR  - https://inrepo02.dkfz.de/record/142207
ER  -