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@ARTICLE{Witt:142207,
      author       = {H. Witt$^*$ and D. Gramatzki and B. Hentschel and K.
                      Pajtler$^*$ and J. Felsberg$^*$ and G. Schackert and M.
                      Löffler and D. Capper$^*$ and F. Sahm$^*$ and M. Sill$^*$
                      and A. von Deimling$^*$ and M. Kool$^*$ and U. Herrlinger
                      and M. Westphal and T. Pietsch and G. Reifenberger$^*$ and
                      S. Pfister$^*$ and J. C. Tonn and M. Weller},
      collaboration = {G. G. Network},
      title        = {{DNA} methylation-based classification of ependymomas in
                      adulthood: implications for diagnosis and treatment.},
      journal      = {Neuro-Oncology},
      volume       = {20},
      number       = {12},
      issn         = {1523-5866},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2019-00021},
      pages        = {1616 - 1624},
      year         = {2018},
      abstract     = {Ependymal tumors are glial tumors that commonly manifest in
                      children and young adults. Their classification has remained
                      entirely morphological until recently, and surgery and
                      radiotherapy are the main treatment options, especially in
                      adults. Here we sought to correlate DNA methylation profiles
                      with clinical and pathological characteristics in the
                      prospective cohort of the German Glioma Network.Tumors from
                      122 adult patients with myxopapillary ependymoma,
                      ependymoma, anaplastic ependymoma, subependymoma, or RELA
                      fusion-positive ependymoma classified according to the World
                      Health Organization (WHO) 2016 were subjected to DNA
                      methylation profiling using the Illumina HumanMethylation450
                      BeadChip platform. Molecular data were correlated with
                      histologic features and clinical characteristics.At a median
                      follow-up of 86.7 months, only 22 patients experienced
                      progression $(18.0\%)$ and 13 patients $(10.7\%)$ died. Each
                      tumor could be assigned to one of the previously defined
                      molecular ependymoma subgroups. All histologic
                      subependymomas corresponded to subependymoma (SE) DNA
                      methylation subgroups, but the reverse was not true: 19
                      histologic ependymomas (WHO grade II) were allocated to
                      molecular SE groups. Similarly, all histological
                      myxopapillary ependymomas were assigned to the molecularly
                      defined spinal myxopapillary ependymoma (SP-MPE) class, but
                      this molecular subgroup additionally included 15 WHO grade
                      II ependymomas by histology. Overall, WHO grade II
                      ependymomas distributed into 7 molecular subgroups.Most
                      adult patients with ependymoma show a favorable prognosis.
                      Molecular classification may provide diagnostic and
                      prognostic information beyond histology and facilitate
                      patient stratification in future clinical trials. The
                      prognostic significance of a subependymoma or myxopapillary
                      ependymoma DNA methylation phenotype without corresponding
                      histology requires further study.1. Ependymoma diagnosed in
                      adult patients most often shows a good prognosis. 2.
                      Molecular classification can support diagnostic and
                      prognostic information beyond histology.},
      cin          = {B062 / G380 / L101 / L401 / L201 / L301 / L701},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)G380-20160331 /
                      I:(DE-He78)L101-20160331 / I:(DE-He78)L401-20160331 /
                      I:(DE-He78)L201-20160331 / I:(DE-He78)L301-20160331 /
                      I:(DE-He78)L701-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30053291},
      pmc          = {pmc:PMC6231197},
      doi          = {10.1093/neuonc/noy118},
      url          = {https://inrepo02.dkfz.de/record/142207},
}