%0 Journal Article
%A Xuan, Yang
%A Gào, Xīn
%A Holleczek, Bernd
%A Brenner, Hermann
%A Schöttker, Ben
%T Prediction of myocardial infarction, stroke and cardiovascular mortality with urinary biomarkers of oxidative stress: Results from a large cohort study.
%J International journal of cardiology
%V 273
%@ 0167-5273
%C Amsterdam [u.a.]
%I Elsevier Science
%M DKFZ-2019-00022
%P 223 - 229
%D 2018
%X Oxidative stress contributes to endothelial dysfunction and is involved in the pathogenesis of cardiovascular diseases (CVD). However, large population-based cohort studies are sparse and biomarkers of oxidative stress have not been evaluated for CVD risk prediction so far.The associations of urinary oxidized guanine/guanosine (OxGua) levels (including 8-hydroxy-2'-deoxyguanosine (8-OHdGuo)) and 8-isoprostane levels with myocardial infarction, stroke and CVD mortality were examined in a population-based cohort of 9949 older adults from Germany with 14 years of follow-up in multivariable adjusted Cox proportional hazards models.Both OxGua and 8-isoprostane levels were associated with CVD mortality independently from other risk factors (hazard ratio (HR) [95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30100224
%R 10.1016/j.ijcard.2018.08.002
%U https://inrepo02.dkfz.de/record/142208