TY  - JOUR
AU  - Xuan, Yang
AU  - Gào, Xīn
AU  - Holleczek, Bernd
AU  - Brenner, Hermann
AU  - Schöttker, Ben
TI  - Prediction of myocardial infarction, stroke and cardiovascular mortality with urinary biomarkers of oxidative stress: Results from a large cohort study.
JO  - International journal of cardiology
VL  - 273
SN  - 0167-5273
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2019-00022
SP  - 223 - 229
PY  - 2018
AB  - Oxidative stress contributes to endothelial dysfunction and is involved in the pathogenesis of cardiovascular diseases (CVD). However, large population-based cohort studies are sparse and biomarkers of oxidative stress have not been evaluated for CVD risk prediction so far.The associations of urinary oxidized guanine/guanosine (OxGua) levels (including 8-hydroxy-2'-deoxyguanosine (8-OHdGuo)) and 8-isoprostane levels with myocardial infarction, stroke and CVD mortality were examined in a population-based cohort of 9949 older adults from Germany with 14 years of follow-up in multivariable adjusted Cox proportional hazards models.Both OxGua and 8-isoprostane levels were associated with CVD mortality independently from other risk factors (hazard ratio (HR) [95
LB  - PUB:(DE-HGF)16
C6  - pmid:30100224
DO  - DOI:10.1016/j.ijcard.2018.08.002
UR  - https://inrepo02.dkfz.de/record/142208
ER  -