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@ARTICLE{Xuan:142208,
      author       = {Y. Xuan$^*$ and X. Gào$^*$ and B. Holleczek and H.
                      Brenner$^*$ and B. Schöttker$^*$},
      title        = {{P}rediction of myocardial infarction, stroke and
                      cardiovascular mortality with urinary biomarkers of
                      oxidative stress: {R}esults from a large cohort study.},
      journal      = {International journal of cardiology},
      volume       = {273},
      issn         = {0167-5273},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2019-00022},
      pages        = {223 - 229},
      year         = {2018},
      abstract     = {Oxidative stress contributes to endothelial dysfunction and
                      is involved in the pathogenesis of cardiovascular diseases
                      (CVD). However, large population-based cohort studies are
                      sparse and biomarkers of oxidative stress have not been
                      evaluated for CVD risk prediction so far.The associations of
                      urinary oxidized guanine/guanosine (OxGua) levels (including
                      8-hydroxy-2'-deoxyguanosine (8-OHdGuo)) and 8-isoprostane
                      levels with myocardial infarction, stroke and CVD mortality
                      were examined in a population-based cohort of 9949 older
                      adults from Germany with 14 years of follow-up in
                      multivariable adjusted Cox proportional hazards models.Both
                      OxGua and 8-isoprostane levels were associated with CVD
                      mortality independently from other risk factors (hazard
                      ratio (HR) $[95\%$ confidence interval] of top vs. bottom
                      tertile: 1.32 [1.06; 1.64] and 1.58 [1.27; 1.98],
                      respectively). Moreover, CVD mortality risk prediction was
                      significantly improved when adding the two biomarkers to the
                      European Society of Cardiology's Systematic Coronary Risk
                      Evaluation (ESC SCORE) tool. The area under the curve (AUC)
                      increased from 0.739 to 0.752 (p = 0.001). In addition,
                      OxGua levels were associated with stroke incidence (HR for 1
                      standard deviation increase: 1.07 [1.01; 1.13]) and
                      8-isoprostane levels were associated with fatal stroke
                      incidence (HR of top vs. bottom tertile: 1.77 [1.09; 2.89]).
                      With respect to myocardial infarction, associations were
                      observed for both biomarkers in obese subjects
                      (BMI ≥ 30 kg/m2).These results from a large cohort
                      study add evidence to the involvement of an imbalanced redox
                      system to the etiology of CVD. In addition, 8-isoprostane
                      and OxGua measurements were shown to be useful for an
                      improved CVD mortality prediction.},
      cin          = {C070 / G110},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)G110-20160331},
      pnm          = {323 - Metabolic Dysfunction as Risk Factor (POF3-323)},
      pid          = {G:(DE-HGF)POF3-323},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30100224},
      doi          = {10.1016/j.ijcard.2018.08.002},
      url          = {https://inrepo02.dkfz.de/record/142208},
}