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@ARTICLE{Yamauchi:142209,
      author       = {Y. Yamauchi and S. Safi and C. Blattner$^*$ and A.
                      Rathinasamy$^*$ and L. Umansky$^*$ and S. Juenger and A.
                      Warth and M. Eichhorn and T. Muley and F. J. F. Herth and H.
                      Dienemann and M. Platten$^*$ and P. Beckhove$^*$ and J.
                      Utikal$^*$ and H. Hoffmann and V. Umansky$^*$},
      title        = {{C}irculating and {T}umor {M}yeloid-derived {S}uppressor
                      {C}ells in {R}esectable {N}on-{S}mall {C}ell {L}ung
                      {C}ancer.},
      journal      = {American journal of respiratory and critical care medicine},
      volume       = {198},
      number       = {6},
      issn         = {1535-4970},
      address      = {New York, NY},
      publisher    = {American Thoracic Society},
      reportid     = {DKFZ-2019-00023},
      pages        = {777 - 787},
      year         = {2018},
      abstract     = {Myeloid-derived suppressor cell (MDSC) expansion has been
                      found to play a role in disease progression in patients with
                      cancer. However, the characteristics of MDSCs in lung cancer
                      are poorly understood.We prospectively investigated MDSCs
                      and inflammatory factors in tumor and peripheral blood
                      samples from patients with resectable non-small cell lung
                      cancer and studied their correlations with the disease
                      prognosis.A complex analysis of MDSC subsets and
                      inflammatory mediators was performed using flow cytometry
                      and a Bio-Plex assay.A significant increase in the frequency
                      of circulating monocytic (M)-MDSCs was observed in the
                      patients with non-small cell lung cancer compared with the
                      healthy donors (HDs). Moreover, the frequencies of M- and
                      polymorphonuclear (PMN)-MDSCs were higher in tumors than in
                      the peripheral blood of the same patients. This accumulation
                      was associated with elevated concentrations of inflammatory
                      mediators involved in MDSC migration to and activation in
                      the tumor microenvironment. An analysis of the MDSC
                      immunosuppressive pattern showed increased programmed
                      death-ligand 1 expression on circulating cells from patients
                      compared with HDs. Tumor PMN-MDSCs displayed higher
                      programmed death-ligand 1 expression levels than the same
                      cells in the peripheral blood. The frequency of CCR5 (C-C
                      chemokine receptor 5) expression on circulating M-MDSCs was
                      significantly higher in the patients than in the HDs.
                      Clinical data analysis revealed negative correlations
                      between recurrence-free survival and the frequencies of
                      PMN-MDSCs and CCR5+ M-MDSCs in the circulation but not in
                      tumors.Our findings suggest that the level of MDSCs in the
                      peripheral blood but not in tumor tissues predicts
                      recurrence after surgery.},
      cin          = {D015 / G300 / G160 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)D015-20160331 / I:(DE-He78)G300-20160331 /
                      I:(DE-He78)G160-20160331 / I:(DE-He78)L101-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29617574},
      doi          = {10.1164/rccm.201708-1707OC},
      url          = {https://inrepo02.dkfz.de/record/142209},
}