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000142252 1001_ $$0P:(DE-He78)914adea2baeb4f2c6a29637da6500048$$aBurigo, Lucas Norberto$$b0$$eFirst author$$udkfz
000142252 245__ $$aSimultaneous optimization of RBE-weighted dose and nanometric ionization distributions in treatment planning with carbon ions.
000142252 260__ $$aBristol$$bIOP Publ.$$c2019
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000142252 520__ $$aInverse treatment planning in intensity modulated particle therapy (IMPT) with scanned carbon-ion beams is currently based on the optimization of RBE-weighted dose to satisfy requirements of target coverage and limited toxicity to organs-at-risk (OARs) and healthy tissues. There are many feasible IMPT plans that meet these requirements, which allows the introduction of further criteria to narrow the selection of a biologically optimal treatment plan. We propose a novel treatment planning strategy based on the simultaneous optimization of RBE-weighted dose and nanometric ionization details (ID) as a new physical characteristic of the delivered plan beyond LET. In particular, we focus on the distribution of large ionization clusters (more than 3 ionizations) to enhance the biological effect across the target volume while minimizing biological effect in normal tissues. Carbon-ion treatment plans for different patient geometries and beam configurations generated with the simultaneous optimization strategy were compared against reference plans obtained with RBE-weighted dose optimization alone. Quality indicators, inhomogeneity index and planning volume histograms of RBE-weighted dose and large ionization clusters were used to evaluate the treatment plans. We show that with simultaneous optimization, ID distributions can be optimized in carbon-ion radiotherapy without compromising the RBE-weighted dose distributions. This strategy can potentially be used to account for optimization of endpoints closely related to radiation quality to achieve better tumor control and reduce risks of complications.
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000142252 7001_ $$aRamos-Méndez, José$$b1
000142252 7001_ $$0P:(DE-He78)fec480a99b1869ec73688e95c2f0a43b$$aBangert, Mark$$b2$$udkfz
000142252 7001_ $$aSchulte, Reinhard W$$b3
000142252 7001_ $$aFaddegon, Bruce$$b4
000142252 773__ $$0PERI:(DE-600)1473501-5$$a10.1088/1361-6560/aaf400$$gVol. 64, no. 1, p. 015015 -$$n1$$p015015 $$tPhysics in medicine and biology$$v64$$x1361-6560$$y2019
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