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| 001 | 142252 | ||
| 005 | 20240229112530.0 | ||
| 024 | 7 | _ | |a 10.1088/1361-6560/aaf400 |2 doi |
| 024 | 7 | _ | |a pmid:30523890 |2 pmid |
| 024 | 7 | _ | |a 0031-9155 |2 ISSN |
| 024 | 7 | _ | |a 1361-6560 |2 ISSN |
| 024 | 7 | _ | |a altmetric:53451031 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2019-00055 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 530 |
| 100 | 1 | _ | |a Burigo, Lucas Norberto |0 P:(DE-He78)914adea2baeb4f2c6a29637da6500048 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Simultaneous optimization of RBE-weighted dose and nanometric ionization distributions in treatment planning with carbon ions. |
| 260 | _ | _ | |a Bristol |c 2019 |b IOP Publ. |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1550840797_11936 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Inverse treatment planning in intensity modulated particle therapy (IMPT) with scanned carbon-ion beams is currently based on the optimization of RBE-weighted dose to satisfy requirements of target coverage and limited toxicity to organs-at-risk (OARs) and healthy tissues. There are many feasible IMPT plans that meet these requirements, which allows the introduction of further criteria to narrow the selection of a biologically optimal treatment plan. We propose a novel treatment planning strategy based on the simultaneous optimization of RBE-weighted dose and nanometric ionization details (ID) as a new physical characteristic of the delivered plan beyond LET. In particular, we focus on the distribution of large ionization clusters (more than 3 ionizations) to enhance the biological effect across the target volume while minimizing biological effect in normal tissues. Carbon-ion treatment plans for different patient geometries and beam configurations generated with the simultaneous optimization strategy were compared against reference plans obtained with RBE-weighted dose optimization alone. Quality indicators, inhomogeneity index and planning volume histograms of RBE-weighted dose and large ionization clusters were used to evaluate the treatment plans. We show that with simultaneous optimization, ID distributions can be optimized in carbon-ion radiotherapy without compromising the RBE-weighted dose distributions. This strategy can potentially be used to account for optimization of endpoints closely related to radiation quality to achieve better tumor control and reduce risks of complications. |
| 536 | _ | _ | |a 315 - Imaging and radiooncology (POF3-315) |0 G:(DE-HGF)POF3-315 |c POF3-315 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 700 | 1 | _ | |a Ramos-Méndez, José |b 1 |
| 700 | 1 | _ | |a Bangert, Mark |0 P:(DE-He78)fec480a99b1869ec73688e95c2f0a43b |b 2 |u dkfz |
| 700 | 1 | _ | |a Schulte, Reinhard W |b 3 |
| 700 | 1 | _ | |a Faddegon, Bruce |b 4 |
| 773 | _ | _ | |a 10.1088/1361-6560/aaf400 |g Vol. 64, no. 1, p. 015015 - |0 PERI:(DE-600)1473501-5 |n 1 |p 015015 |t Physics in medicine and biology |v 64 |y 2019 |x 1361-6560 |
| 909 | C | O | |o oai:inrepo02.dkfz.de:142252 |p VDB |
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| 914 | 1 | _ | |y 2019 |
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