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000142277 041__ $$aeng
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000142277 1001_ $$0P:(DE-He78)6e02c183f41e45a5867dec393fb4616a$$aAmitay, Efrat$$b0$$eFirst author$$udkfz
000142277 245__ $$aSystematic review: Gut microbiota in fecal samples and detection of colorectal neoplasms.
000142277 260__ $$aAustin, Tex.$$bLandes Bioscience$$c2018
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000142277 520__ $$aColorectal cancer (CRC) is a leading cause of cancer morbidity and mortality. Dysbiosis in the gut microbiota may be associated with CRC. This systematic review focuses on differences in gut microbial community between people diagnosed with CRC or adenoma and healthy individuals using fecal samples, emphasizing non-invasive fecal microbiome models for CRC early diagnosis. Nineteen studies were identified in a systematic literature search of Pubmed, Web of Science and ScienceDirect. Several bacteria were reported to differ in abundance between CRC and adenoma cases and healthy controls, with Fusobacterium the most common. Fecal multi-bacterial predictive models used to distinguish CRC patients from healthy controls had reported areas under the receiver operating curve (AUCs) in external validation populations of 0.68-0.77. Though advanced sequencing techniques could in the future complement current non-invasive methods for CRC early detection, more studies with high statistical power, comparable and reproducible methods and external validation of predictive models are needed.
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000142277 7001_ $$0P:(DE-He78)78a9df7108a5b079145be1cb1ab6a315$$aKrilaviciute, Agne$$b1$$udkfz
000142277 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b2$$eLast author$$udkfz
000142277 773__ $$0PERI:(DE-600)2575755-6$$a10.1080/19490976.2018.1445957$$gVol. 9, no. 4, p. 1 - 15$$n4$$p293-307$$tGut microbes$$v9$$x1949-0984$$y2018
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