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@ARTICLE{Ast:142283,
      author       = {V. Ast and T. Kordass$^*$ and M. Oswald and A. Kolte and D.
                      Eisel$^*$ and W. Osen$^*$ and S. Eichmüller$^*$ and A.
                      Berndt and R. König},
      title        = {{M}i{R}-192, mi{R}-200c and mi{R}-17 are
                      fibroblast-mediated inhibitors of colorectal cancer
                      invasion.},
      journal      = {OncoTarget},
      volume       = {9},
      number       = {85},
      issn         = {1949-2553},
      address      = {[S.l.]},
      publisher    = {Impact Journals LLC},
      reportid     = {DKFZ-2019-00066},
      pages        = {35559-35580},
      year         = {2018},
      note         = {Ast V*, Kordass T* (*=eqal contribution)},
      abstract     = {Colorectal cancer remains a leading cause of cancer-related
                      death worldwide. A previous transcriptomics based study
                      characterized molecular subgroups of which the stromal
                      subgroup was associated with the worst clinical outcome.
                      Micro-RNAs (miRNAs) are well-known regulators of gene
                      expression and can follow a non-linear repression mechanism.
                      We set up a model combining piecewise linear and linear
                      regression and applied this combined regression model to a
                      comprehensive colon adenocarcinoma dataset. We identified
                      miRNAs involved in regulating characteristic gene sets,
                      particularly extracellular matrix remodeling in the stromal
                      subgroup. Comparison of expression data from separated
                      (epithelial) cancer cells and stroma cells or fibroblasts
                      associate these regulatory interactions with infiltrating
                      stromal or tumor-associated fibroblasts. MiR-200c, miR-17
                      and miR-192 were identified as the most promising candidates
                      regulating genes crucial for extracellular matrix
                      remodeling. We validated our computational findings by in
                      vitro assays. Enforced expression of either miR-200c, miR-17
                      or miR-192 in untransformed human colon fibroblasts
                      down-regulated $85\%$ of all predicted target genes.
                      Expressing these miRNAs singly or in combination in human
                      colon fibroblasts co-cultured with colon cancer cells
                      considerably reduced cancer cell invasion validating these
                      miRNAs as cancer cell infiltration suppressors in tumor
                      associated fibroblasts.},
      cin          = {G182},
      ddc          = {610},
      cid          = {I:(DE-He78)G182-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30473751},
      pmc          = {pmc:PMC6238973},
      doi          = {10.18632/oncotarget.26263},
      url          = {https://inrepo02.dkfz.de/record/142283},
}