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@ARTICLE{Chouaib:142311,
      author       = {S. Chouaib and V. Umansky$^*$ and C. Kieda},
      title        = {{T}he role of hypoxia in shaping the recruitment of
                      proangiogenic and immunosuppressive cells in the tumor
                      microenvironment.},
      journal      = {Contemporary oncology},
      volume       = {22},
      number       = {1A},
      issn         = {1428-2526},
      address      = {Poznań},
      reportid     = {DKFZ-2019-00094},
      pages        = {7 - 13},
      year         = {2018},
      abstract     = {Hypoxia characterizes growing tumors and contributes
                      significantly to their aggressiveness. Hypoxia-inducible
                      factors (HIFs 1 and 2) are stabilized and act differentially
                      as transcription factors on tumor growth and are responsible
                      for important cancer hallmarks such as pathologic
                      angiogenesis, cellular proliferation, apoptosis,
                      differentiation and genetic instability as well as affecting
                      tumor metabolism, tumor immune responses, invasion and
                      metastasis. Taking into account the tumor tissue as a whole
                      and considering the interplay of the various partners which
                      react with hypoxia in the tumor site lead to reconsideration
                      of the treatment strategies. Key limitations of treatment
                      success result from the adaptation to the hypoxic milieu
                      sustained by tumor anarchic angiogenesis. This raises immune
                      tolerance by influencing the recruitment of
                      immunosuppressive cells as bone marrow derived suppressor
                      cells (MDSC) or by impairing the infiltration and killing of
                      tumor cells by cytotoxic cells at the level of the
                      endothelial cell wall of the hypoxic tumor vessels, as
                      summarized in the schematic abstract.},
      subtyp        = {Review Article},
      cin          = {G300},
      ddc          = {530},
      cid          = {I:(DE-He78)G300-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29628788},
      pmc          = {pmc:PMC5885081},
      doi          = {10.5114/wo.2018.73874},
      url          = {https://inrepo02.dkfz.de/record/142311},
}