%0 Journal Article
%A Machiraju, Devayani
%A Moll, Iris
%A Gebhardt, Christoffer
%A Sucker, Antje
%A Buder-Bakhaya, Kristina
%A Schadendorf, Dirk
%A Hassel, Jessica
%T STAT5 expression correlates with recurrence and survival in melanoma patients treated with interferon-α.
%J Melanoma research
%V 28
%N 3
%@ 0960-8931
%C [s.l.]
%I Ovid
%M DKFZ-2019-00198
%P 204-210
%D 2018
%X Interferons (IFN) have a direct growth-inhibiting effect on tumor cells through Janus kinase-dependent activation of the transcription factor signal transducer and activator of transcription (STAT1). In vitro, signaling through STAT5 has been demonstrated to counteract this effect and lead to IFN resistance of melanoma cell lines. In 32 patients treated with IFN-α in an adjuvant setting, we investigated paraffin-embedded tumor tissue from primary melanomas and melanoma metastases for expression of STAT3 and STAT5, by immunohistochemistry, and for expression of phosphorylated signaling transduction activating transcription factor (pSTAT)3 and pSTAT5, by immunofluorescence. Tumor cell expression levels of these proteins were correlated with patient characteristics and clinical outcomes. The patient cohort consisted of 12 (37.5
%K Interferon-alpha (NLM Chemicals)
%K STAT5 Transcription Factor (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29485532
%R 10.1097/CMR.0000000000000435
%U https://inrepo02.dkfz.de/record/142479